Dynamic control of extracellular environment in in vitro neural recording systems.

IEEE Trans Neural Syst Rehabil Eng

Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53706, USA.

Published: June 2005

A technique is presented for rapid fabrication of microfluidic channels on top of multichannel in vitro neural recording electrode arrays. The channels allow dynamic control of both stable and transient flow patterns over localized areas of the array, over biologically relevant timescales. A cellular model consisting of thermally sensitive dorsal root ganglion neurons was integrated into the devices. The device was used to demonstrate precise control of the extracellular microenvironment of individual cells on the array. Since the methods presented here are not specific to a particular cell type or neural recording system, the technique is amenable to a wide range of applications within the neuroscience field.

Download full-text PDF

Source
http://dx.doi.org/10.1109/TNSRE.2005.848685DOI Listing

Publication Analysis

Top Keywords

neural recording
12
dynamic control
8
control extracellular
8
vitro neural
8
extracellular environment
4
environment vitro
4
recording systems
4
systems technique
4
technique presented
4
presented rapid
4

Similar Publications

Cognitive control deficits and increased intra-subject variability have been well established as core characteristics of attention deficit hyperactivity disorder (ADHD), and there is a growing interest in their expression at the neural level. We aimed to study neural variability in ADHD, as reflected in theta inter-trial phase coherence (ITC) during error processing, a process that involves cognitive control. We examined both traditional event-related potential (ERP) measures of error processing (i.

View Article and Find Full Text PDF

Heat acclimation defense against exertional heat stroke by improving the function of preoptic TRPV1 neurons.

Theranostics

January 2025

Department of Critical Care Medicine and Department of Anaesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China, 710032.

Record-breaking heatwaves caused by greenhouse effects lead to multiple hyperthermia disorders, the most serious of which is exertional heat stroke (EHS) with the mortality reaching 60 %. Repeat exercise with heat exposure, termed heat acclimation (HA), protects against EHS by fine-tuning feedback control of body temperature (Tb), the mechanism of which is opaque. This study aimed to explore the molecular and neural circuit mechanisms of the HA training against EHS.

View Article and Find Full Text PDF

Radiomic signatures of brain metastases on MRI: utility in predicting pathological subtypes of lung cancer.

Transl Cancer Res

December 2024

Department of Radiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

Background: The pathological sub-classification of lung cancer is crucial in diagnosis, treatment and prognosis for patients. Quick and timely identification of pathological subtypes from imaging examinations rather than histological tests could help guiding therapeutic strategies. The aim of the study is to construct a non-invasive radiomics-based model for predicting the subtypes of lung cancer on brain metastases (BMs) from multiple magnetic resonance imaging (MRI) sequences.

View Article and Find Full Text PDF

Former studies have established that individuals with a cochlear implant (CI) for treating single-sided deafness experience improved speech processing after implantation. However, it is not clear how each ear contributes separately to improve speech perception over time at the behavioural and neural level. In this longitudinal EEG study with four different time points, we measured neural activity in response to various temporally and spectrally degraded spoken words presented monaurally to the CI and non-CI ears (5 left and 5 right ears) in 10 single-sided CI users and 10 age- and sex-matched individuals with normal hearing.

View Article and Find Full Text PDF

LiNbO domain structures have been widely applied in nonlinear beam shaping, quantum light generation, and nonvolatile ferroelectric memory. The recent developments in nanoscale domain engineering techniques make it possible to fabricate sub-diffracted nanodomains in LiNbO crystal for high-speed modulation and high-capacity storage. However, it still lacks a feasible and efficient way to characterize these nanoscale domains.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!