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Preparation and sustained-release mechanism of hydroxybutyl chitosan/graphene oxide temperature-sensitive hypoglycaemic subcutaneous implants.
Colloids Surf B Biointerfaces
April 2024
School of Pharmaceutical Sciences, Liaoning University, Shenyang 110036, China; LiaoNing University Judicial Authentication Centre, Shenyang 110036, China. Electronic address:
The current situation of diabetes prevention and control is extremely severe. For instance, glimepiride (GLM), a third-generation sulfonylurea, demonstrates suboptimal clinical efficacy in oral dosage forms, which underscores the pressing need for the development of a new dosage form. Recently, in situ gel subcutaneous implants have garnered considerable attention.
View Article and Find Full Text PDFComparative pharmacokinetic evaluation of glimepiride orodispersable and conventional tablets in rabbits.
Drug Dev Ind Pharm
February 2024
Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah.
Objectives: Glimepiride Orodispersable Tablets (ODT) were prepared with the goal to have rapid onset of action and higher bioavailability with ease administration to individuals with swallowing difficulty to ameliorate patient compliance.
Significance: Glimepiride is a contemporary hypoglycemic medication that belongs to the family of sulfonylurea derivatives. It is used in type 2 diabetes mellitus.
Transdermal Delivery of Glimepiride: A Novel Approach Using Nanomicelle-Embedded Microneedles.
Pharmaceutics
July 2023
Department of Pharmacy, Qurtaba University of Science and Information Technology, Peshawar 25000, Pakistan.
Glimepiride (GM) is a hydrophobic drug that dissolves slowly and yields inconsistent clinical responses after oral administration. Transdermal drug delivery (TDD) is an appropriate alternative to oral administration. Microneedles (MNs) offer a promising delivery system that penetrates the skin, while polymeric micelles can enhance the solubility; hence, the combination of both results in high drug bioavailability.
View Article and Find Full Text PDFImplications of Pharmacokinetic Potentials of Pioglitazone Enantiomers in Rat Plasma Mediated through Glucose Uptake Assay.
Molecules
June 2023
Department of Pharmaceutical Chemistry, JSS Academy of Higher Education & Research, Mysore 570015, India.
Pioglitazone, a PPAR-gamma activator used to diagnose hyperglycemia, was studied for its stereoselective deposition and active enantiomers in female albino Wistar rats. In accordance with USFDA recommendations, a bioanalytical technique was employed to assess the segregation of pioglitazone enantiomers in rat plasma with glimepiride as an internal standard. A Phenomenox i-Amylose-3 column (150 mm × 4.
View Article and Find Full Text PDFEarth-friendly micellar UPLC technique for determination of four hypoglycemic drugs in different pharmaceutical dosage forms and spiked human plasma.
BMC Chem
July 2023
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University, Badr, 11829, Egypt.
A novel, sensitive, and green micellar UPLC method was proposed and validated for the simultaneous determination of four hypoglycemic agents used in type II diabetes mellitus treatment namely, pioglitazone, alogliptin, glimepiride, and vildagliptin. The developed UPLC method was successfully applied for quantitative analysis of these drugs in bulk, in pharmaceutical formulations, and in spiked human plasma. Chromatographic separation was carried out on a Kinetex® 1.
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