Inspired by nature: an exploration of biocatalyzed siloxane bond formation and cleavage.

Curr Opin Biotechnol

Dow Corning Corporation, 2200 West Salzburg Road, Midland, Michigan 48686-0994, USA.

Published: August 2005

The intricate siliceous architectures of diatom species have inspired our exploration of biosilicification. In vitro studies of natural systems within the area of silica biosynthesis are complicated. Previous studies, which included biomimetic approaches, often failed to recognize the chemistry of silicic acid and its analogues. To better understand the role of various proteins in the biosilicification process, recent studies have been conducted to test the ability of enzymes to catalyze the formation and cleavage of siloxane bonds. Notably, biocatalysis at silicon was observed. Further understanding of the biotransformation strategy in the design and synthesis of structurally complex materials would be beneficial.

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http://dx.doi.org/10.1016/j.copbio.2005.06.003DOI Listing

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