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Chronic Lymphocytic Leukemia: 2025 Update on the Epidemiology, Pathogenesis, Diagnosis, and Therapy.
Am J Hematol
January 2025
Department I of Internal Medicine and Medical Faculty, University of Cologne, Köln, Germany.
Disease Overview: Chronic lymphocytic leukemia (CLL) is the most frequent type of leukemia. It typically occurs in older patients and has a highly variable clinical course. Leukemic transformation is initiated by specific genomic alterations that interfere with the regulation of proliferation and apoptosis in clonal B-cells.
View Article and Find Full Text PDFFishPi: a bioinformatic prediction tool to link piRNA and transposable elements.
Mob DNA
January 2025
School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Background: Piwi-interacting RNAs (piRNA)s are non-coding small RNAs that post-transcriptionally affect gene expression and regulation. Through complementary seed region binding with transposable elements (TEs), piRNAs protect the genome from transposition. A tool to link piRNAs with complementary TE targets will improve our understanding of the role of piRNAs in genome maintenance and gene regulation.
View Article and Find Full Text PDFNew taxa of butterflies supported by genomic analysis.
Taxon Rep Int Lepid Surv
November 2024
Department of Biophysics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9050, USA.
Continuing with the genomic analysis of butterflies, we present a taxonomic update. As a result of this work, 3 genera, 6 subgenera, 16 species, and 2 subspecies are described as new. New genera and subgenera are (type species in parenthesis): Grishin, ( W.
View Article and Find Full Text PDFGenomic analysis reveals hidden species diversity in Fabricius (Lepidoptera: Riodinidae).
Insecta mundi
November 2024
Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-9050 USA.
Genomic analysis of [Fabricius], 1807 (Lepidoptera: Riodinidae Grote, 1895) reveals species richness higher than anticipated. As a result, one subgenus, 22 species, and one subspecies are proposed as new (type species or type localities in parenthesis): Grishin, ( Prittwitz, 1865), () Grishin, (Peru: Rio Pachitea, Monte Alegre), () Grishin, (Guyana: Cuyuni-Mazaruni), () Grishin, (Brazil: Santa Catarina), () Grishin, (Panama: Darién), () Grishin, (Ecuador: Santo Domingo), () Grishin, (Peru: Cuzco), () Grishin, (Panama: Chiriquí), () Grishin, (Mexico: Tamaulipas), () Grishin, (Mexico: Nuevo León), () Grishin, (Argentina: Salta), () Grishin, (Peru: Piura), () Grishin, (Bolivia: La Paz), () Grishin, (Mexico: Sonora), () Grishin, (Peru: Madre de Dios), () Grishin, (Bolivia: La Paz), () Grishin, (Mexico: Chiapas), () Grishin, (Panama: Darién), () Grishin, (Panama: Darién), () Grishin, (Panama: Darién), () Grishin, (Panama: Panamá), () Grishin, (Peru: Cuzco), () Grishin, (Brazil: São Paulo), and () Grishin, (Brazil: Paraná). The following five taxa are (not subspecies): () Schaus, 1928, (not () (Linnaeus, 1767)), () Stichel, 1910, (not () Westwood, 1851), () Stichel, 1929, (not () Godman and Salvin, 1886), () R.
View Article and Find Full Text PDFRefinement of Atomic Polarizabilities for a Polarizable Gaussian Multipole Force Field with Simultaneous Considerations of Both Molecular Polarizability Tensors and In-Solution Electrostatic Potentials.
J Chem Inf Model
January 2025
Departments of Molecular Biology and Biochemistry, Chemical and Biomolecular Engineering, Materials Science and Engineering, and Biomedical Engineering, University of California, Irvine, Irvine, California 92697, United States.
Atomic polarizabilities are considered to be fundamental parameters in polarizable molecular mechanical force fields that play pivotal roles in determining model transferability across different electrostatic environments. In an earlier work, the atomic polarizabilities were obtained by fitting them to the B3LYP/aug-cc-pvtz molecular polarizability tensors of mainly small molecules. Taking advantage of the recent PCMRESPPOL method, we refine the atomic polarizabilities for condensed-phase simulations using a polarizable Gaussian Multipole (pGM) force field.
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