Human cytomegalovirus (HCMV) can cause serious problems after hematopoietic stem cell transplantation. The death of a pediatric transplant recipient after reactivation of a postnatal HCMV infection with bilateral retinitis and pneumonitis is described. Sequencing of the HCMV UL97 region revealed a compartment-specific mutation (H520Q) in urine conferring ganciclovir resistance.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1169106 | PMC |
| http://dx.doi.org/10.1128/JCM.43.7.3551-3554.2005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring Novel Strategies to Alleviate Symptoms of β-Globinopathies: Examining the Potential Role of Embryonic ε-globin Induction.
Transfus Med Rev
October 2024
Department of Pathology, Brigham and Women's Hospital, Boston, MA, United States. Electronic address:
Article Synopsis
- β-thalassemia and sickle cell disease are common genetic blood disorders caused by mutations in the β-globin gene, leading to anemia and requiring treatments like blood transfusions and bone marrow transplants.
- New research is exploring the potential of inducing ε-globin expression, which was previously thought non-inducible postnatally, as a way to improve treatment outcomes for these conditions.
- The review highlights the need for further research into the mechanisms of ε-globin silencing and suggests future drug development initiatives to harness its therapeutic benefits.
Novel Porcine Model Reveals Two Distinct LGR5 Cell Types During Lung Development and Homeostasis.
Am J Respir Cell Mol Biol
November 2024
North Carolina State University at Raleigh, Raleigh, North Carolina, United States.
Article Synopsis
- Cells expressing LGR5 are crucial for homeostasis and regeneration in various organs, but their function in the human lung has not been well studied, especially compared to findings from mouse models.
- Utilizing a new transgenic pig model, researchers identified two significant populations of LGR5 cells in the lung that are similar to those found in humans but not in mice.
- The study reveals that LGR5 expression occurs transiently in fetal lung progenitor cells and is absent in postnatal lungs but can be reactivated in specific organoid models, highlighting the complex roles of LGR5 cells in lung development and potential for repair.
The de novo purine synthesis enzyme Adssl1 promotes cardiomyocyte proliferation and cardiac regeneration.
Sci Signal
October 2024
Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.
There is a short window during which the neonatal heart has the proliferative capacity to completely repair damage, an ability that is lost in adulthood. Inducing proliferation in adult cardiomyocytes by reactivating cell cycle reentry after myocardial infarction (MI) improves cardiac function. De novo purine synthesis is a critical source of nucleotides for cell proliferation.
View Article and Find Full Text PDFReinitiating lung development: a novel approach in the management of bronchopulmonary dysplasia.
Respir Res
October 2024
Department of Pediatrics, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, 110004, China.
Article Synopsis
- * Current BPD management mainly uses medications and changes in ventilatory techniques, but these don't fully correct the underlying lung issues.
- * New treatments focusing on stem/progenitor cell differentiation and growth factors are crucial for improving lung development in BPD, with ongoing research highlighting their potential to restore healthy lung structure and function.
The impact of maternal anti-inflammatory drugs on surgical anesthesia-induced neuroinflammation and cognitive impairment in offspring mice.
Front Cell Neurosci
October 2024
Department of Anesthesiology and Critical Care Medicine, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: The impact of maternal surgery combined with general anesthesia on neuroinflammation and the development of learning and memory impairment in offspring remains unclear. This study utilized a pathogen-free laparotomy model to investigate these changes during the second trimester, as well as their response to anti-inflammatory therapy.
Methods: C57BL/6 pregnant mice at the 14.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!