Severe efavirenz-induced hypersensitivity syndrome (not-DRESS) with acute renal failure.

J Infect

Infectious Diseases and Tropical Medicine Unit, Department of Clinical and Surgical Sciences, University of Las Palmas de Gran Canaria, Plaza Dr Pasteur s/n, 35080 Las Palmas, Spain.

Published: February 2006

AI Article Synopsis

  • A patient from Sub-Saharan Africa with HIV and disseminated tuberculosis experienced a severe hypersensitivity reaction to the medication efavirenz.
  • The reaction led to acute renal failure, as well as issues with the liver and lungs.
  • Notably, the patient did not show skin symptoms or elevated eosinophil levels, which are often associated with allergic reactions.

Article Abstract

We report on a Subsaharian patient with HIV infection and disseminated tuberculosis who developed acute, severe hypersensitivity reaction to efavirenz including acute renal failure in addition to liver and lung involvement, in the absence of skin changes or blood eosinophilia.

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Source
http://dx.doi.org/10.1016/j.jinf.2005.05.020DOI Listing

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