Purpose: To compare the Para Mixed technique for irradiation of the internal mammary nodes (IMN) with three commonly used strategies, by analyzing the dose to the heart and other organs at risk.
Methods And Materials: Four different three-dimensional conformal dose plans were created for 30 breast cancer patients. The IMN were enclosed with the Para Mixed technique by a widened mediolateral tangent photon beam and an anterior electron beam, with the Patched technique by an anterior electron beam, with the Standard technique by an anterior photon and electron beam, and with the PWT technique by partially wide tangents. All techniques were optimized for conformality and produced equally adequate target coverage.
Results: Heart dose was lowest with the Para Mixed and Patched technique for all patients and with the PWT technique for right-sided treatment only. Lung dose was highest with the PWT, lowest with the Patched, and intermediate with the Para Mixed and Standard techniques. Skin dose was highest with the Patched, lowest with the PWT, and intermediate with the Para Mixed and the Standard techniques. The Para Mixed technique resulted in a 13-Gy lower dose in an overlap area, and the PWT technique was the only technique that incorporated considerable volumes of the contralateral breast.
Conclusion: The Para Mixed technique yielded the overall best results. No other technique resulted in a lower heart dose. Lung and skin were equally spared instead of one of them being compromised, and the contralateral breast was avoided.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijrobp.2005.04.027 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
DFT Study of Structural, Electronic, and Charge-Transfer Properties of 2-Naphthol Azo Derivatives: Geometric, Positional, and Substituent Effects.
J Phys Chem A
January 2025
Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
This work represents a systematic computational study of structural and optoelectronic properties of 24 phenylazo-2-naphthol derivatives using the DFT-B3LYP/6-31 + G(d,p) method. The positional isomers of azo compounds have been designed by introducing an azophenyl unit (with and without substituents) at three different (1-, 3-, and 4-) positions of 2-naphthols. This result shows that depending on the linking position of the azophenyl unit and substituents (NO and maleimide), the -azo, -azo, and hydrazo forms of our substituted azo derivatives possess distinguished UV-vis absorption and charge-transfer properties compared to unsubstituted Sudan I derivatives.
View Article and Find Full Text PDFKinetic and structural investigation of the 4-allyl syringol oxidase from Streptomyces cavernae.
Arch Biochem Biophys
January 2025
Microbial Biotechnology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Universitaetsstrasse 150, 44780 Bochum, Germany.
4-Phenol oxidases are proposed to be involved in the utilization of lignin-derived aromatic compounds. While enzymes with selectivity towards 4-hydroxyphenyl and guaiacyl motifs are well described, we identified the first syringyl-specific oxidase from Streptomyces cavernae (Sc4ASO) only very recently. Here, in-depth studies were conducted to unravel the molecular origins of the outstanding selectivity of Sc4ASO.
View Article and Find Full Text PDFAssociation between mixed exposure of non-persistent pesticides and liver fibrosis in the general US population: NHANES 2013-2016.
Ecotoxicol Environ Saf
January 2025
Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, PR China. Electronic address:
People are continually and simultaneously exposed to various non-persistent pesticides as these chemicals are ubiquitously distributed in the environment. Toxicological studies have indicated the associations between non-persistent pesticides and liver fibrosis in vitro and in vivo. However, epidemical study on the deleterious effect of non-persistent pesticides on the risk of liver fibrosis is rather limited.
View Article and Find Full Text PDFSarcoptes scabiei infestation in llamas (Lama glama) of the Argentine Puna: Clinical study, and morphological and molecular mite identification.
Vet Parasitol Reg Stud Reports
January 2025
Instituto de Investigación y Desarrollo Tecnológico para la Agricultura Familiar - Región NOA (IPAF NOA), Instituto Nacional de Tecnología Agropecuaria (INTA), Posta de Hornillos, 4624 Jujuy, Argentina.
Sarcoptic mange has been described in domestic South American camelids (SACs), exported to non-Andean countries, and in wild SAC in their natural habitat. Reports on the incidence of this infestation in llamas or alpacas raised in their original location, on the other hand, are missing. The present study aimed to detect and characterize cases of sarcoptic mange in herds of llamas (Lama glama) raised in the high plateau region (Puna) of the province of Jujuy, Argentina.
View Article and Find Full Text PDFHyphenation of 2D NMR With Hydrogenative PHIP.
Magn Reson Chem
January 2025
Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
Parahydrogen induced polarisation (PHIP) is often used to enhance the sensitivity of NMR, with the purpose of extending the applicability of the technique. Nuclear spin hyperpolarisation obtained via PHIP is generally localised on the protons derived from the addition of para-enriched hydrogen to an unsaturated substrate. This limitation has been previously addressed by pulse schemes that can spread this hyperpolarised magnetisation through the entire network of J-coupled protons in the product molecule.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!