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Probabilistic Physiologically Based Pharmacokinetic Model for Penicillin G in Milk From Dairy Cows Following Intramammary or Intramuscular Administrations.
Toxicol Sci
July 2018
Institute of Computational Comparative Medicine (ICCM), Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506.
Penicillin remains one of the most frequently identified violative drug residues in food-producing animals. The predominant violations of penicillin were found in cull dairy cows. In the United States, procaine penicillin G is approved to be used in dairy cows through intramuscular (IM) and intramammary (IMM) administrations.
View Article and Find Full Text PDFElimination kinetics of ceftiofur hydrochloride in milk after an 8-day extended intramammary administration in healthy and infected cows.
PLoS One
December 2017
State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, P. R. China.
Ceftiofur hydrochloride (CEF) is occasionally used for the intramammary (IMM) treatment of mastitis. This extralabel manner could result in a drug-residue violation of the milk. The objective of this study was to determine the elimination kinetics of IMM CEF in lactating dairy cattle.
View Article and Find Full Text PDFDepletion of florfenicol in lactating dairy cows after intramammary and subcutaneous administration.
J Vet Pharmacol Ther
December 2016
Division of Applied Veterinary Research, U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, MD, USA.
Eighteen Holstein dairy cows ranging in body weight from 500-700 kg and with an average milk yield of 37 ± 6 kg/day were used to investigate the depletion of florfenicol (FFL) in milk and plasma of dairy cows. Three groups of six were administered FFL: Group A, intramammary (IMM) infusion of ~2.5 mg FFL/kg BW at three consecutive milking intervals (total amount of ~7.
View Article and Find Full Text PDFTreatments of clinical mastitis occurring in cows on 51 large dairy herds in Wisconsin.
J Dairy Sci
September 2014
Department of Dairy Science, University of Wisconsin, Madison 53706. Electronic address:
Antimicrobials are frequently used for treatment of bovine mastitis and few studies have examined modern treatment strategies on large US dairy farms. The objective of this study was to describe treatment practices for clinical mastitis occurring in cows on large dairy herds in Wisconsin. Treatments performed on 747 cows experiencing cases of mild, moderate, or severe symptoms of clinical mastitis were recorded on 51 Wisconsin dairy farms.
View Article and Find Full Text PDFAssessment and promotion of judicious antibiotic use on dairy farms in Washington State.
J Dairy Sci
August 2006
Communicable Disease Control Program, Tacoma-Pierce County Health Department, Tacoma, WA 98418, USA.
The aims of this study were to describe antibiotic use and biosecurity practices among Washington State dairy producers and to evaluate the effectiveness of a collaborative approach to promoting judicious antibiotic use on dairy farms. In collaboration with a statewide industry group, Washington State dairy producers participated in a written, self-administered survey in 2003. They were then provided several educational interventions followed by a second written survey in 2005.
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