AI Article Synopsis
- The study investigated the cytogenetic status of peripheral lymphocytes in 67 patients with drug-sensitive pulmonary tuberculosis, revealing signs of chromosomal disorganization before and 2 months into intensive chemotherapy.
- The disorganization was characterized by elevated cell levels and structural changes in chromosomes, with more severe effects noted in infiltrative and disseminated forms of tuberculosis compared to caseous pneumonia.
- Patients with infiltrative tuberculosis also showed reduced lymphocytic DNA repair activity, which normalized after completing chemotherapy.
Article Abstract
The cytogenic status of peripheral lymphocytes was studied in 67 patients with drug-sensitive pulmonary tuberculosis. The latter was found to be attended by cytogenetic disorganization whose signs were present before and 2 months of intensive chemotherapy. In pulmonary tuberculosis, structural disorganization in the lymphocytic chromosomal apparatus was characterized by the elevated levels of cells and with changes in the structure and number of chromosomes. They are most pronounced in infiltrative and disseminated tuberculosis than in caseous pneumonia, as well as 2 months after rather than before chemotherapy. Patients with infiltrative pulmonary tuberculosis had also decreased lymphocytic activity of DNA reparation, followed by its normalization after a course of chemotherapy.
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