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Surface Acoustic Wave-Driven Enhancement of Enzyme-Linked Immunosorbent Assays: ELISAW.
Anal Chem
June 2024
Medically Advanced Devices Laboratory, Center for Medical Devices, Department of Mechanical and Aerospace Engineering, Jacobs School of Engineering, and the Department of Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive MC0411, La Jolla, California 92093, United States.
Enzyme-linked immunosorbent assays (ELISAs) are widely used in biology and clinical diagnosis. Relying on antigen-antibody interaction through diffusion, the standard ELISA protocol can be time-consuming, preventing its use in rapid diagnostics. We present a time-saving and more sensitive ELISA without changing the standard setup and protocol, using surface acoustic waves (SAWs) to enhance performance.
View Article and Find Full Text PDFApplication of Statistical Analysis and Machine Learning to Identify Infants' Abnormal Suckling Behavior.
IEEE J Transl Eng Health Med
May 2024
Medically Advanced Devices LaboratoryDepartment of Mechanical and Aerospace EngineeringJacobs School of Engineering, University of California at San Diego La Jolla CA 92093 USA.
Objective: Identify infants with abnormal suckling behavior from simple non-nutritive suckling devices.
Background: While it is well known breastfeeding is beneficial to the health of both mothers and infants, breastfeeding ceases in 75 percent of mother-child dyads by 6 months. The current standard of care lacks objective measurements to screen infant suckling abnormalities within the first few days of life, a critical time to establish milk supply and successful breastfeeding practices.
Alzheimer's disease (AD) is a debilitating condition that affects millions of people worldwide. One promising strategy for detecting and monitoring AD early on is using extracellular vesicles (EVs)-based point-of-care testing; however, diagnosing AD using EVs poses a challenge due to the low abundance of EV-biomarkers. Here, we present a fully integrated organic electrochemical transistor (OECT) that enables high accuracy, speed, and convenience in the detection of EVs from AD patients.
View Article and Find Full Text PDFGlycocalyx transduces membrane leak in brain tumor cells exposed to sharp magnetic pulsing.
Biophys J
November 2023
VA San Diego Healthcare System, San Diego, California; Veterans Medical Research Foundation, San Diego, California; Department of Medicine, Division of Pulmonary & Critical Care, University of California San Diego, La Jolla, California; Glycobiology Research and Training Center, University of California San Diego, La Jolla, California. Electronic address:
Mechanisms by which electric (E) or magnetic (B) fields might be harnessed to affect tumor cell behavior remain poorly defined, presenting a barrier to translation. We hypothesized in early studies that the glycocalyx of lung cancer cells might play a role in mediating plasma membrane leak by low-frequency pulsed magnetic fields (Lf-PMF) generated on a low-energy solenoid platform. In testing glioblastoma and neuroblastoma cells known to overexpress glycoproteins rich in modifications by the anionic glycan sialic acid (Sia), exposure of brain tumor cells on the same platform to a pulse train that included a 5 min 50Hz Lf-PMF (dB/dt ∼ 2 T/s at 10 ms pulse widths) induced a very modest but significant protease leak above that of control nonexposed cells (with modest but significant reductions in long-term tumor cell viability after the 5 min exposure).
View Article and Find Full Text PDFOnset of Visible Capillary Waves from High-Frequency Acoustic Excitation.
Langmuir
March 2023
Medically Advanced Devices Laboratory, Center for Medical Device Engineering and Biomechanics, Department of Mechanical and Aerospace Engineering, Jacobs School of Engineering, University of California San Diego, La Jolla, California 92093-0411, United States.
Remarkably, the interface of a fluid droplet will produce visible capillary waves when exposed to acoustic waves. For example, a small (∼1 μL) sessile droplet will oscillate at a low ∼10 Hz frequency when weakly driven by acoustic waves at ∼10 Hz frequency and beyond. We measured such a droplet's interfacial response to 6.
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