A new potential ligand for paramagnetic complexes acting as a receptor-specific MRI contrast agent was investigated by means of one- and two-dimensional NMR spectroscopy and mass spectrometry. A complete assignment of the structure is reported.
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http://dx.doi.org/10.1002/mrc.1610 | DOI Listing |
iRadiology
June 2024
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Positron emission tomography (PET) is a noninvasive molecular imaging technique that utilizes biologically active radiolabeled compounds to image biochemical processes. As such, PET can provide important pathophysiological information associated with pain of different etiologies. As such, the information obtained using PET often combined with MRI or CT can provide useful information for diagnosing and monitoring changes associated with pain.
View Article and Find Full Text PDFTaiwan J Ophthalmol
September 2022
Department of Electrical Engineering, Yuan Ze University, Chung-Li, Taoyuan, Taiwan.
Optic neuritis, an optic nerve inflammatory disease presenting with acute unilateral or bilateral visual loss, is one of the core symptoms of neuromyelitis optica spectrum disorder (NMOSD). The diagnosis of NMOSD-related optic neuritis is challenging, and it is mainly based on clinical presentation, optical coherence tomography, magnetic resonance imaging scans, and the status of serum aquaporin-4 antibodies. In the pathogenesis, aquaporin-4 antibodies target astrocytes in the optic nerves, spinal cord and some specific regions of the brain eliciting a devastating autoimmune response.
View Article and Find Full Text PDFJ Headache Pain
September 2022
Department of Neurology, Lanzhou University Second Hospital, Cuiying Gate, No. 82Linxia Road, Chengguan District, Lanzhou, 730000, China.
Background: Chronic migraine is a common and highly disabling disorder. Functional MRI has indicated that abnormal brain region activation is linked with chronic migraine. Drugs targeting the calcitonin gene-related peptide (CGRP) or its receptor have been reported to be efficient for treating chronic migraine.
View Article and Find Full Text PDFCancers (Basel)
August 2022
Department of Nuclear Medicine, Ulm University Medical Center, 89081 Ulm, Germany.
Inhibition studies in small animals are the standard for evaluating the specificity of newly developed drugs, including radiopharmaceuticals. Recently, it has been reported that the tumor accumulation of radiotracers can be assessed in the chorioallantoic membrane (CAM) model with similar results to experiments in mice, such contributing to the 3Rs principles (reduction, replacement, and refinement). However, inhibition studies to prove receptor-specific binding have not yet been performed in the CAM model.
View Article and Find Full Text PDFHum Brain Mapp
May 2022
Forschungszentrum Jülich, Institute of Neuroscience and Medicine 4, INM-4, Jülich, Germany.
The glutamate and γ-aminobutyric acid neuroreceptor subtypes mGluR and GABA are hypothesized to be involved in the development of a variety of psychiatric diseases. However, detailed information relating to their in vivo distribution is generally unavailable. Maps of such distributions could potentially aid clinical studies by providing a reference for the normal distribution of neuroreceptors and may also be useful as covariates in advanced functional magnetic resonance imaging (MR) studies.
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