Objective: Several studies have suggested that there is an occupational component to the causation of non-Hodgkin lymphoma (NHL). We aimed to use accurate means to assess occupational exposures to solvents, metals, organic dusts and polychlorinated biphenyls (PCBs) in a case-control study.
Methods: Cases were incident NHLs during 2000 and 2001 in two regions of Australia. Controls were randomly selected from the electoral roll and frequency matched to cases by age, sex and region. A detailed occupational history was taken from each subject. For jobs with likely exposure to the chemicals of interest, additional questions were asked by telephone interview using modified job specific modules. An expert allocated exposures using the information in the job histories and the interviews. Odds ratios were calculated for each exposure adjusting for age, sex, region and ethnic origin.
Results: 694 cases and 694 controls (70 and 45 respectively of those potentially eligible) participated. The risk of NHL was increased by about 30 for exposure to any solvent with a dose response relationship, subgroup analysis showed the finding was restricted to solvents other than benzene. Exposure to wood dust also increased the risk of NHL slightly. Exposures to other organic dusts, metals, and PCBs were not strongly related to NHL.
Conclusions: The risk of NHL appears to be increased by exposure to solvents other than benzene and possibly to wood dust.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10552-004-7845-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comprehensive characterization of European house dust contaminants: Concentrations and profiles, geographical variability, and implications for chemical regulation and health risk.
Sci Total Environ
December 2024
Flemish Institute for Technological Research (VITO), Unit Materials and Chemistry (MATCH), 2400 Mol, Belgium.
Article Synopsis
- - This study explores the levels and geographical differences of contaminants found in house dust across Europe, identifying over 1200 anthropogenic compounds using advanced techniques like mass spectrometry and suspect screening.
- - The research indicates that contaminant concentrations vary less than threefold within Europe, showing similarities with North American dust due to shared consumer products and materials.
- - It highlights geographical patterns, revealing that certain contaminants increased from north to south (like PAHs and chlorinated paraffins), whereas others, like biocides, decreased; it also emphasizes a significant risk from older, restricted contaminants, like DEHP and PCBs, despite limited toxicity data available for newer compounds.
Impact of occupational exposures in patients with chronic obstructive pulmonary disease: current understanding and knowledge gaps.
Curr Opin Pulm Med
November 2024
University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Article Synopsis
- COPD is commonly linked to tobacco use, but various occupational exposures like dust and air quality issues are also significant risk factors that are often overlooked.
- Historical exposures include both inorganic and organic dusts, while modern work environments raise new concerns such as indoor air quality and outdoor pollution from industries like ridesharing.
- More research is essential to understand the relationship between occupational hazards and COPD, focusing on precision medicine and improving workplace health initiatives.
Occurrence of legacy and emerging organophosphate flame retardants (OPFRs) on silicone wristbands: Comparison within couples.
Sci Total Environ
December 2024
Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China. Electronic address:
Article Synopsis
- Novel organophosphate flame retardants (OPFRs) are frequently found in indoor dust, and wristbands were used to measure personal exposure among 93 adults in Beijing, revealing differences in OPFR profiles compared to the U.S.
- Emerging OPFRs like DEGBBCPP and BEHPP were detected in over 45% of wristbands, with DEGBBCPP being significantly more concentrated than the legacy OPFR TDCIPP.
- Gender differences in exposure were noted, as husbands had higher levels of TBOEP and DEGBBCPP, while wives showed higher levels of EHDPP, indicating different sources and patterns of exposure.
Aconitate decarboxylase 1 mediates the acute airway inflammatory response to environmental exposures.
Front Immunol
October 2024
Division of Allergy & Immunology, Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
Background: Environmental lipopolysaccharide (LPS) and microbial component-enriched organic dusts cause significant lung disease. These environmental exposures induce the recruitment and activation of distinct lung monocyte/macrophage subpopulations involved in disease pathogenesis. Aconitate decarboxylase 1 () was one of the most upregulated genes following LPS (vs.
View Article and Find Full Text PDFHypersensitivity pneumonitis to phthalic anhydride: Case description and review of the literature.
Allergol Select
August 2024
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), and.
Article Synopsis
- Hypersensitivity pneumonitis (HP) is an uncommon lung allergy primarily caused by inhaling organic dusts, with rare instances linked to chemicals like phthalates found in plastics.
- A clinical case involving a cable production worker demonstrated that symptoms initially diagnosed as idiopathic pulmonary fibrosis were linked to chronic HP resulting from exposure to phthalates, confirmed by specific IgG antibodies and other clinical findings.
- The study highlights the need for greater awareness of phthalates as potential triggers for occupational HP, as it has not been commonly recognized in previous case reports.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!