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Time-Dependent Shifts in Intestinal Bacteriome, Colonization and Incidence of Antibiotic-Resistance Genes after Allogeneic Hematopoietic Stem Cell Transplantation.
Biomedicines
July 2024
R. Gorbacheva Memorial Research Institute of Pediatric Oncology, Hematology and Transplantation, Pavlov First State Medical University of St. Petersburg, L. Tolstoy St, 6-8, 197022 St. Petersburg, Russia.
Article Synopsis
- Dose-intensive therapies during allogeneic hematopoietic stem cell transplantation (allo-HSCT) significantly disrupt gut microbiota and promote antibiotic resistance, with recovery patterns poorly understood.
- In a study of 12 adult patients, stool samples revealed a marked decline in microbial diversity starting from day 0, persisting for up to a year, with specific bacterial genera showing slower recovery.
- A rise in antibiotic-resistant bacteria was observed around day 30 post-transplant, with resistance to major antibiotic classes, but a gradual decrease in resistance levels was noted over the following year.
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing.
Nat Commun
March 2024
Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK.
Supporting cell proliferation through nucleotide biosynthesis is an essential requirement for cancer cells. Hence, inhibition of folate-mediated one carbon (1C) metabolism, which is required for nucleotide synthesis, has been successfully exploited in anti-cancer therapy. Here, we reveal that mitochondrial folate metabolism is upregulated in patient-derived leukaemic stem cells (LSCs).
View Article and Find Full Text PDFDevelopment of fast-dissolving dosage forms of curcuminoids by electrospinning for potential tumor therapy application.
Int J Pharm
January 2022
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), H-1111 Budapest, Hungary.
Curcuminoids (CUs) of antitumor and various other potential biological activities have extremely low water solubility therefore special formulation was elaborated. New fast dissolving reconstitution dosage forms of four CUs were prepared as fibrous form of 2-hydroxypropyl-β-cyclodextin (HP-β-CD). In the electrospinning process HP-β-CD could act both as solubilizer and fiber-forming agent.
View Article and Find Full Text PDFAn Improved LC-MS/MS Method for the Analysis of Thirteen Cytostatics on Workplace Surfaces.
Pharmaceuticals (Basel)
July 2021
LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal.
Cytostatics are drugs used in cancer treatment, which pose serious risks to healthcare workers. Dermal absorption via surface contamination is the key exposure route; thus, rapid, reliable, and validated analytical methods for multicomponent detection are crucial to identify the exposure risk. A surface-wipe-sampling technique compatible with hospitals' safety requirements (gauze, 1 mL isopropanol) and a fast and simple extraction method (1 mL acetonitrile, 20 min ultrasonic bath, evaporation, reconstitution in 200 µL acetonitrile), coupled with liquid chromatography-tandem mass spectrometry analysis, were developed.
View Article and Find Full Text PDFThe course of Kaposi's sarcoma, a marker disease for the initial diagnosis of AIDS, under ongoing cART.
Clin Hemorheol Microcirc
December 2020
Klinik- und Poliklinik für Haut-und Geschlechtskrankheiten, Universitätsmedizin Greifswald, Greifswald, Germany.
While Kaposi's sarcoma (KS) was common in the 1980s and early 1990s in HIV-positive patients and one of the most common AIDS-defining diseases, its prevalence today has decreased significantly due to the early and widespread use of chimeric antigen receptor T-cell (cART) therapy. The rapid initiation of cART or, if occurring during ongoing cART, an optimization of antiretroviral therapy leads to a healing of this tumour disease in most patients. The aim of the therapy is immune reconstitution, as the immunodeficiency resulting from the HIV disease (reduced CD4+-T helper cells) promotes the development and spread of KS.
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