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WNT and TGF-Beta Pathway Alterations in Early-Onset Colorectal Cancer Among Hispanic/Latino Populations.
Cancers (Basel)
November 2024
Department of Integrative Translational Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Background/objectives: One of the fastest-growing minority groups in the U.S. is the Hispanic/Latino population.
View Article and Find Full Text PDFNanoclay gels attenuate BMP2-associated inflammation and promote chondrogenesis to enhance BMP2-spinal fusion.
Bioact Mater
February 2025
Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Bone morphogenetic protein 2 (BMP2) is clinically applied for treating intractable fractures and promoting spinal fusion because of its osteogenic potency. However, adverse effects following the release of supraphysiological doses of BMP2 from collagen carriers are widely reported. Nanoclay gel (NC) is attracting attention as a biomaterial, given the potential for localized efficacy of administered agents.
View Article and Find Full Text PDFThe polinton-like supergroup of viruses: evolution, molecular biology, and taxonomy.
Microbiol Mol Biol Rev
September 2024
Institut Pasteur, Université Paris Cité, Archaeal Virology Unit, Paris, France.
SUMMARYPolintons are 15-20 kb-long self-synthesizing transposons that are widespread in eukaryotic, and in particular protist, genomes. Apart from a transposase and a protein-primed DNA polymerase, polintons encode homologs of major and minor jelly-roll capsid proteins, DNA-packaging ATPases, and proteases involved in capsid maturation of diverse eukaryotic viruses of kingdom . Given the conservation of these structural and morphogenetic proteins among polintons, these elements are predicted to alternate between transposon and viral lifestyles and, although virions have thus far not been detected, are classified as viruses (class ) in the phylum .
View Article and Find Full Text PDFMidterm Outcomes of Multimodal Approach to Treating Severe Scoliosis in Patients With Osteogenesis Imperfecta.
J Am Acad Orthop Surg
September 2024
From the Department of Orthopaedic Surgery, Nemours Children's Health, Wilmington, DE (Hori, Thornley, Almeida da Silva, Kaymaz, Rogers, Yorgova, Bober, Carroll, Kruse, Franzone, Shah), and the Department of Orthopaedic Surgery, University of South Alabama Health, Mobile, AL (McDonald).
Article Synopsis
- The surgical management of scoliosis in patients with osteogenesis imperfecta (OI) is complicated by factors such as rigid spinal curves, short stature, and fragile bones, prompting a study on various treatment methods.
- A retrospective review of 30 OI patients (average age 14.1 years) who underwent posterior spinal fusion revealed significant improvements in major curve correction and other spinal parameters after a minimum follow-up of 2 years.
- Complications were minimal, with only two patients experiencing issues like proximal junctional kyphosis, indicating the approach's effectiveness and safety in addressing severe scoliosis in OI patients.
Characterization of bovine long non-coding RNAs, OOSNCR1, OOSNCR2 and OOSNCR3, and their roles in oocyte maturation and early embryonic development.
Reprod Biol
September 2024
Laboratory of Animal Biotechnology and Genomics, Division of Animal and Nutritional Sciences, West Virginia University, Morgantown, WV 26506, United States. Electronic address:
Article Synopsis
- This study explores the roles of three long non-coding RNAs (OOSNCR1, OOSNCR2, and OOSNCR3) in bovine oocyte development and early embryogenesis, highlighting their expression patterns in somatic tissues and ovarian follicles during maturation.
- The lncRNAs were found to be primarily expressed in fetal ovaries and oocytes, peaking during oocyte maturation and decreasing after fertilization, with no expression by the 16-cell stage.
- Knockdown experiments showed that disrupting these lncRNAs led to reduced oocyte survival and impaired blastocyst development, indicating their crucial role in oocyte competency and early developmental processes.
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