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Expecting factors for inadequate glycemic control in children and adolescents with type 1 diabetes mellitus: a single center experience.
J Diabetes Metab Disord
December 2024
Department of Pediatrics, College of Medicine, University of Mosul, Mosul, Iraq.
Objectives: Achieving an ideal glycemic control in children and adolescents with type 1 diabetes mellitus (T1DM) is both a difficult and challenging process. We aim to highlight the expected factors contributing to inadequate glycemic control in children and adolescents with T1DM in a sample of Iraqi children and adolescents.
Methods: This was a descriptive cross-sectional study that recruited 247 T1DM patients aged < 18 years & disease duration ≥ 1 year.
Outpatient diabetes management influences glycemic control for critically ill patients during nutrition support: A retrospective observational study.
Nutr Clin Pract
February 2025
Department of Surgery, University of Tennessee Health Science Center College of Medicine, Memphis, Tennessee, USA.
Article Synopsis
- The study aimed to assess how well outpatient diabetes management affects glycemic control in hospitalized patients.
- Adult patients in a trauma intensive care unit were analyzed based on their diabetes status through metrics like hemoglobin A1c (Hgb A1c) and blood glucose levels.
- Results showed that patients with uncontrolled diabetes required significantly more insulin and had less time within the target blood glucose range compared to those with controlled diabetes or no diabetes, indicating the need for early detection of uncontrolled diabetes for better management.
Is It Time for a New Algorithm for the Pharmacotherapy of Steroid-Induced Diabetes?
J Clin Med
September 2024
Department of Endocrinology, Centre of Postgraduate Medical Education, Marymoncka St. 99/103, 01-813 Warsaw, Poland.
Glucocorticoids (GS) are widely used in multiple medical indications due to their anti-inflammatory, immunosuppressive, and antiproliferative effects. Despite their effectiveness in treating respiratory, skin, joint, renal, and neoplastic diseases, they dysregulate glucose metabolism, leading to steroid-induced diabetes (SID) or a significant increase of glycemia in people with previously diagnosed diabetes. The risk of adverse event development depends on the prior therapy, the duration of the treatment, the form of the drug, and individual factors, i.
View Article and Find Full Text PDFTransitioning to Insulin Analogs in Tunisian Children with Type 1 Diabetes: Efficacy and Safety.
Tunis Med
August 2024
Pediatrics and Neonatology departement , Yasminette Ben Arous , Tunisia. University El Manar, Faculty of Medecine of Tunis.
Introduction: there is a lack of research evaluating the impact of therapeutic switching from human insulin to analogues, particularly in paediatric populations from low- and middle-income countries.
Aim: The study aimed to retrospectively assess the effectiveness and safety of transitioning from human insulin to insulin analogs in Tunisian children with diabetes.
Methods: This retrospective descriptive study included children with type 1 diabetes who changed their insulin therapy protocol after at least one year of treatment with human insulin.
Higher Order Structure Differences Among Insulin Crystalline Drugs Revealed by 2D heteronuclear NMR.
ChemMedChem
December 2024
Office of Pharmaceutical Quality Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD-20993, United States.
During therapeutic protein development, two-dimensional (2D) heteronuclear NMR spectra can be a powerful analytical method for measuring protein higher order structure (HOS) in solution since the spectra exhibit much higher resolution than homonuclear H spectra. However, 2D NMR capabilities for characterizing protein HOS in crystalline states remain to be assessed, given the low C natural abundance and intrinsically broader lines in solid-state NMR (SSNMR). Herein, high-resolution heteronuclear correlation (HETCOR) SSNMR was utilized to directly measure intact crystal drug products of insulin human, insulin analogs of insulin lispro and insulin aspart.
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