Five compounds have been isolated from Fructus Rubi. On the basis of spectral analysis and physicochemical properties, their structures were establised as 4-hydroxy-3-methoxybenzoic acid (I), p-hydroxybenzoic acid (II), gallic acid (III), tiliroside (IV) and ellagic acid (V). I, II and III were found from the plant for the first time.

Download full-text PDF

Source

Publication Analysis

Top Keywords

acid iii
8
[studies chemical
4
chemical constituents
4
constituents fructus
4
fructus rubi]
4
rubi] compounds
4
compounds isolated
4
isolated fructus
4
fructus rubi
4
rubi basis
4

Similar Publications

Ganaxolone: A Review in Epileptic Seizures Associated with Cyclin-Dependent Kinase-Like 5 Deficiency Disorder.

Paediatr Drugs

January 2025

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Oral ganaxolone (ZTALMY), a synthetic analogue of the endogenous neuroactive steroid allopregnanolone, acts as a positive allosteric modulator of synaptic and extra-synaptic γ-aminobutyric acid (GABA) type A receptor function in the CNS. In the EU and the UK, it is approved for the adjunctive treatment of epileptic seizures associated with cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) in patients aged 2-17 years. In a multinational phase III study (Marigold), 17 weeks' therapy with adjunctive ganaxolone, administered orally three times daily with food, significantly reduced 28-day major motor seizure frequency from baseline versus placebo in patients aged 2-19 years with CDD-associated refractory epilepsy.

View Article and Find Full Text PDF

An RNase III-processed sRNA coordinates sialic acid metabolism of during gut colonization.

Proc Natl Acad Sci U S A

January 2025

Key Laboratory of Medical Molecular Virology (Ministry of Education / National Health Commission / Chinese Academy of Medical Sciences), Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200033, China.

Sialic acids derived from colonic mucin glycans are crucial nutrients for enteric bacterial pathogens like . The uptake and utilization of sialic acid in depend on coordinated regulons, each activated by specific metabolites at the transcriptional level. However, the mechanisms enabling crosstalk among these regulatory circuits to synchronize gene expression remain poorly understood.

View Article and Find Full Text PDF

Prussian blue nanoparticles (PBNPs) have been identified as a promising candidate for biomimetic peroxidase (POD)-like activity, specifically due to the metal centres (Fe/Fe) of Prussian blue (PB), which have the potential to function as catalytically active centres. The decoration of PBNPs with desired functional polymers (such as amino- or carboxylate-based) primarily facilitates the subsequent linkage of biomolecules to the nanoparticles for their use in biosensor applications. Thus, the elucidation of the catalytic POD mimicry of these systems is of significant scientific interest but has not been investigated in depth yet.

View Article and Find Full Text PDF

New Insights on Iron-Trimesate MOFs for Inorganic As(III) and As(V) Adsorption from Aqueous Media.

Nanomaterials (Basel)

December 2024

Unidad Departamental de Química Analítica, Departamento de Química, Facultad de Ciencias, Universidad de La Laguna, Avda. Astrofísico Fco. Sánchez, s/n, 38206 La Laguna, Spain.

Arsenic contamination of water endangers the health of millions of people worldwide, affecting certain countries and regions with especial severity. Interest in the use of Fe-based metal organic frameworks (MOFs) to remove inorganic arsenic species has increased due to their stability and adsorptive properties. In this study, the performance of a synthesized Nano-{Fe-BTC} MOF, containing iron oxide octahedral chains connected by trimesic acid linkers, in adsorbing As(III) and As(V) species was investigated and compared with commercial BasoliteF300 MOF.

View Article and Find Full Text PDF

Magnetocaloric Effect in 3D Gd(III)-Oxalate Coordination Framework.

Nanomaterials (Basel)

December 2024

Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, School of Materials Science and Engineering, Institutes of Physical Science and Information Technology, Anhui University, Hefei 230601, China.

Cryogenic magnetic refrigerants based on the magnetocaloric effect (MCE) hold significant potential as substitutes for the expensive and scarce He-3. Gd(III)-based complexes are considered excellent candidates for low-temperature magnetic refrigerants. We have synthesized a series of Ln(III)-based metal-organic framework (MOF) (Ln = Gd/Dy) by the slow release of oxalates in situ from organic ligands (disodium edetate dehydrate (EDTA-2Na) and thiodiglycolic acid).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!