Simultaneous liver transplantation may reduce the risk of intestinal transplant rejection. We have recently developed two new models of combined liver/intestine transplantation (LIT) in the rat to study this phenomenon. Herein, we report our experience with LIT using a single donor (SD) or multiple donors (MD). Large volumes of fluid were required to prevent a drop in the mean arterial pressure during the anhepatic phase in the SD recipients. Many of the SD recipients died of intraoperative hypovolemic shock (57%). The MD recipients had a shorter anhepatic time (12 +/- 1 minutes vs. 17 +/- 2 minutes; P less than 0.01) and a shorter warm intestinal ischemia time (15 +/- 1 minutes vs. 32 +/- 2 minutes; P less than 0.01). Operative mortality rates were much lower in the MD recipients (10% vs. 68%; P less than 0.01). The long-term survival rate using MD was 71% at 1 month. Graft function was normal in the long-term survivors. LIT with MD provides a good model to study the immunological effects of multivisceral grafting.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/micr.1920130306 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The effects of dance on maternal childbirth: a systematic review and meta-analysis.
BMC Pregnancy Childbirth
January 2025
School of Nursing, Chongqing Medical University, Chongqing, 400016, China.
Background: Previous guidelines have clearly stated that dance is safe and beneficial during pregnancy and for childbirth. However, due to the small sample size of individual studies and different interventions, there were inconsistencies about the effect of dance on maternal childbirth.
Methods: We included studies evaluating the effect of dance on women in labor.
Real-world evidence of remdesivir in formerly hospitalized COVID-19 patients: patient-reported and functional outcomes.
BMC Infect Dis
January 2025
Department of Pulmonology, Semmelweis University, Budapest, Hungary.
Background: Post-COVID condition (PCC) is characterized by persisting symptoms after the resolution of acute COVID-19. Remdesivir (RDV), a broad-spectrum antiviral drug, has been widely used in patients hospitalized with COVID-19 requiring oxygen therapy. We aimed to evaluate the effects of RDV on PCC by assessing patient-reported and functional outcomes.
View Article and Find Full Text PDFA 12-month retrospective review of pressure injury plastic surgical flap techniques utilizing pure hypochlorous acid (pHA) preserved wound solution for wound bed preparation.
Wound Manag Prev
December 2024
Chief, Division of Plastic and Reconstructive Surgery, Tulane University School of Medicine, New Orleans, LA.
Background: The presence of heavy microbial colony formation, polymicrobial infection, and local altered pH contribute to the high rate of postoperative complications following surgical reconstruction of stage IV pressure injuries (PIs).
Purpose: The objective of this study was to determine the rate of bacteria-related postoperative complications following surgical reconstruction of stage IV PIs in which a pure hypochlorous acid (pHA) antimicrobially preserved wound cleaning solution was used.
Methods: This 1-year retrospective review evaluated the outcomes of patients who underwent surgical reconstructive treatment of chronic stage IV PI.
Patient-reported and surgical outcomes of profunda artery perforator (PAP) flap breast reconstructions compared to deep inferior epigastric perforator (DIEP) using BREAST-Q.
J Plast Reconstr Aesthet Surg
February 2024
Plastic Surgery Department, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK. Electronic address:
Background: Autologous breast reconstruction patients require thorough assessment, with the profunda femoris artery perforator (PAP) flap having become an important autologous reconstruction option alongside the deep inferior epigastric perforator (DIEP) flap. Breast reconstruction impacts patients psychologically, physically and mentally. The BREAST-Q aids in the assessment of patient-reported outcome measures (PROMs).
View Article and Find Full Text PDFIntramolecular distance-regulated G4 DNA enzymatic activity-based chromophotometric system for visual monitoring of diquat.
Anal Chim Acta
January 2025
Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, PR China. Electronic address:
Background: As global food production continues to surge, the widespread use of herbicides has also increased concurrently, posing challenges like health risks and environmental pollution. Traditional detection methods for pesticide residues, such as diquat (DQ), were hampered by limitations like high expenses, lengthy detection times and complex operations, restricting their practical application in rapid clinical diagnosis.
Results: In light of the pressing necessity for the identification of minute pesticide residues and the intrinsic constraints of small molecule analysis, a novel chromophotometric biosensor targeting small molecules was developed based on bi-epitopes on single antibody to immobilize two DQ-PAL, inhibiting the hybridization of DQ-PAL.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!