AI Article Synopsis
- CART peptide is a new neurotransmitter linked to reward and drug abuse, showing notable activity in the brain's dopamine systems.
- In the nucleus accumbens, about 86% of CART peptide-containing neurons also have substance P, indicating a significant interaction, while CART and enkephalin do not co-exist in this area.
- The colocalization of CART and substance P neurons follows a gradient, with more overlap in the front (rostral) parts of the nucleus accumbens, suggesting CART neurons may play an important role in the brain's reward pathways.
Article Abstract
CART peptide is a novel neurotransmitter that, due to its distribution in the brain and its modulation of dopamine systems, may be involved in aspects of reward and drug abuse. In the nucleus accumbens (NAcc), CART peptide immunoreactivity (IR) is colocalized with substance P-IR in neurons. Approximately 86% of CART-IR cells colocalize with substance P, while only 19% of substance P-IR neurons contain CART. CART peptide does not colocalize with enkephalin-IR in this region. The substance P-CART colocalization exists in a rostro-caudal gradient with more colocalization in rostral regions. The presence of CART in substance P NAcc neurons suggests that CART neurons may be a subset of the basal ganglia direct pathway or that CART neurons are involved in limbic projections of the NAcc, such as to the ventral pallidum.
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| http://dx.doi.org/10.1016/j.brainres.2005.05.025 | DOI Listing |
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