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Irbesartan May Ameliorate Ventricular Remodeling by Inhibiting CREB-Mediated Cardiac Aldosterone Synthesis in Rats with Myocardial Infarction.
Int J Mol Sci
December 2024
Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510800, China.
Irbesartan improves ventricular remodeling (VR) following myocardial infarction (MI). This study investigates whether irbesartan attenuates VR by reducing aldosterone production in the heart and its underlying mechanisms. MI was induced in male Sprague-Dawley rats through coronary artery ligation.
View Article and Find Full Text PDFRenal protection by acacetin in streptozotocin-induced diabetic nephropathy via TLR4/NF-κB pathway modulation in rats.
Adv Clin Exp Med
January 2025
Department of Acupuncture and Rehabilitation, Chunan Campus of Hangzhou Traditional Chinese Medicine Hospital, Chunan County Hospital of Traditional Chinese Medicine, Hangzhou, China.
Background: Diabetic nephropathy (DN), the most severe microvascular consequence of diabetes mellitus (DM), is the precursor to end-stage renal disease (ESRD). The development of problems linked to DN involves both oxidative damage and inflammation. Natural flavone acacetin (AC) has anti-inflammatory, antioxidant and anti-cancer properties.
View Article and Find Full Text PDFPotential cardioprotective effect of paroxetine against ventricular remodeling in an animal model of myocardial infarction: a comparative study.
BMC Pharmacol Toxicol
December 2024
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Background: Post-myocardial infarction (MI) remodeling involves various structural and functional changes, such as inflammation and fibrosis. Upregulation of G protein-coupled receptor kinase 2 (GRK2) is linked to the progression of cardiovascular diseases, including myocardial infarction. The inhibitory effects of paroxetine on GRK2 are recognized, yet its protective effect on post-MI remodeling has not been elucidated.
View Article and Find Full Text PDFSex differences in the efficacy of angiotensin receptor blockers on kidney and cardiovascular outcomes among individuals with type 2 diabetes and diabetic kidney disease: post hoc analyses of the RENAAL and IDNT trials.
Diabetologia
December 2024
Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Aims/hypothesis: Our aim was to assess sex differences in the efficacy of angiotensin receptor blockers (i.e. losartan and irbesartan) on kidney and cardiovascular outcomes in individuals with type 2 diabetes and diabetic kidney disease.
View Article and Find Full Text PDFInvestigating the presence, distribution and risk of pharmaceutically active compounds (PhACs) in wastewater treatment plants, river sediments and fish.
Chemosphere
November 2024
Unit of Persistent Organic Pollutants and Emerging Pollutants in Environment, Department of Environment, CIEMAT, Avda. Complutense 40, 28040, Madrid, Spain. Electronic address:
The increasing consumption of medicines and the lack of efficient technologies in wastewater treatment plants (WWTPs) can release pharmaceutically active compounds (PhACs) into any given river with the subsequent risk to the environment and human health. To assess the occurrence and transfer pathways of PhACs through the river ecosystem, 22 PhACs and one metabolite were analyzed in WWTPs, river sediments and fish collected alongside the Tagus River basin between 2020 and 2022. All the matrices presented at least two drugs being azithromycin the only one quantified in all of them.
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