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Near IR emitting isothiocyanato-substituted fluorophores: their synthesis and bioconjugation to monoclonal antibodies. | LitMetric
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Near IR emitting isothiocyanato-substituted fluorophores: their synthesis and bioconjugation to monoclonal antibodies.

Wubiao Duan Karen Smith Huguette Savoie John Greenman Ross W Boyle

Org Biomol Chem

University of Hull, Department of Chemistry and Clinical Biosciences Institute, Hull, UKHU6 7RX.

Published: July 2005

Two near IR emitting fluorophores, based on the phthalocyanine and naphthalocyanine chromophores, which also bear a single isothiocyanato group suitable for conjugation to proteins are reported; their utility as luminescent probes is demonstrated by conjugation to monoclonal antibodies and the ability of these conjugates to selectively bind cells bearing the relevant antigen.

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 Source
http://dx.doi.org/10.1039/b504334dDOI Listing

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