AI Article Synopsis
- This mini-review focuses on the antimicrobial and antiangiogenic properties of squalamine, a steroid derived from dogfish sharks.
- Squalamine has potential applications in treating various diseases, including cancers and age-related macular degeneration (AMD).
- The findings raise the question of whether squalamine could be regarded as a versatile drug for future medical use.
Article Abstract
The purpose of this mini-review is to summarize and highlight the different advances in our understanding of the antimicrobial and antiangiogenic activity of squalamine, a cationic steroid isolated in 1993 from the dogfish shark Squalus Acanthias. Indeed, squalamine has shown to be useful for the treatment of important diseases such as cancers (lung, ovarian, brain and others), age-related macular degeneration (AMD) and the control of body weight in man. All these results led to a question: could we consider squalamine as a polyvalent drug of the future?
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| http://dx.doi.org/10.2174/1568009054064642 | DOI Listing |
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Article Synopsis
- This mini-review focuses on the antimicrobial and antiangiogenic properties of squalamine, a steroid derived from dogfish sharks.
- Squalamine has potential applications in treating various diseases, including cancers and age-related macular degeneration (AMD).
- The findings raise the question of whether squalamine could be regarded as a versatile drug for future medical use.
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