The functionally active part of influenza virus hemagglutinin was investigated through the synthesis of a series of peptides representing different parts of the intersubunit region. Secondary structure prediction, circular dichroism and Fourier transform infrared spectroscopic studies were undertaken to investigate the secondary structure of these peptides. The peptide fragments were found to adopt multiple conformations, depending on their concentration in solution, the presence of the non-ionic detergent octyl-beta-D-glucoside and the polarity of the solvent. The results of biological studies with these peptide fragments are discussed in relation to their conformation, as inferred from the spectroscopic analysis.

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1432-1033.1992.tb16942.xDOI Listing

Publication Analysis

Top Keywords

intersubunit region
8
influenza virus
8
virus hemagglutinin
8
secondary structure
8
peptide fragments
8
conformational functional
4
functional properties
4
properties peptides
4
peptides covering
4
covering intersubunit
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!