AI Article Synopsis
- - Changes in diet, particularly high-calorie and high-fat diets, may contribute to an increase in allergic diseases.
- - This study aimed to assess how different fat levels in diets affected skin reactivity and cytokine levels in mice.
- - Results showed that mice on a high-fat diet had increased histamine skin reactivity and higher levels of interleukin-4, indicating a potential link between fat consumption and stronger allergic responses.
Article Abstract
Changes in diet may be associated with the increase in allergic disease; change to high-calorie and high-fat diets may be a factor. In this study our objective was to determine skin reactivity of histamine and serum cytokine concentrations in mice fed diets containing different amounts of fat. Histamine reactivity was performed on mice back skin and serum cytokine concentrations were measured by ELISA in mice injected with anti-CD3 antibody. We measured serum interferon-gamma as a Th1-type cytokine and interleukin-4 as a Th2-type cytokine. Mice fed a high fat diet displayed enhanced skin reactivity of histamine and higher IL-4 levels in serum. These data suggest that a high fat diet may play a role in enhancing allergic reactions.
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| http://dx.doi.org/10.1016/j.imbio.2004.12.003 | DOI Listing |
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