In vitro durability testing was conducted on the Penn State/3M electric total artificial heart (ETAH) to determine device durability and to evaluate device failures. A specialized mock circulatory loop was developed for this testing. Customized software continuously acquired data during the test period, and failures were analyzed using FMEA (failure modes and effects analysis) and FMECA (failure modes, effects, and criticality analysis) principles. Redesigns were implemented when appropriate. Reliability growth principles were then applied to calculate the 1 and 2 year reliability. The 1 and 2 year reliability of the Penn State/3M ETAH was shown to be 96.1% and 59.9%, respectively, at 80% confidence.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/01.mat.0000159385.32989.7c | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Engineering performance and environmental assessment of sustainable concrete incorporating nano silica and metakaolin as cementitious materials.
Sci Rep
January 2025
School of Civil Engineering, Vellore Institute of Technology, Chennai, Tamil Nadu, 600127, India.
The carbon footprint associated with cement production, coupled with depletion of natural resources and climate change, underscores the need for sustainable alternatives. This study explores the effect of metakaolin (MK) and nano-silica (NS) on concrete's engineering performance and environmental impact. Initially, compressive, tensile, and flexural strength tests, along with durability assessments like water absorption, sorptivity, rapid chloride permeability, and resistance to acid and sulphate attacks, were conducted.
View Article and Find Full Text PDFFinite element investigation for improving chest wall reconstruction process using ceramic and polymeric implants.
Sci Rep
January 2025
Biomedical Engineering Department, Faculty of Engineering, Helwan University, Cairo, Egypt.
Car accidents, infections caused by bacteria or viruses, metastatic lesions, tumors, and malignancies are the most frequent causes of chest wall damage, leading to the removal of the affected area. After excision, artificial bone or synthetic materials are used in chest wall reconstruction to restore the skeletal structure of the chest. Chest implants have traditionally been made from metallic materials like titanium alloys due to their biocompatibility and durability.
View Article and Find Full Text PDFBinding a stimulus after, but not before, response execution: examining the temporal binding window of event files.
Psychol Res
January 2025
University of Toronto, Toronto, Canada.
Efficient and flexible responses are essential for successfully interacting with the environment. These interactions require an instantaneous integration of visual stimuli and responses, known as 'stimulus-response binding' (SR binding). SR binding is considered part of a holistic temporary representation, the event file, that integrates the stimulus, the response, and the action effect produced by this response.
View Article and Find Full Text PDFBackground: We aim to repurpose the widely used adjuvant and immunomodulator Alhydrogel at a specific dose and schedule (AD04) as a disease-modifying treatment for mild Alzheimer's disease (AD). AD04 is a potent adjuvant commonly used in vaccines and allergy immunotherapies to augment the magnitude and durability of the immune response. Our preliminary data come from a clinical Phase 2 study in which AD04 served as a control arm.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Center for Alzheimer's Research and Treatment, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
Background: Medical history and healthcare utilization in preclinical Alzheimer's disease (AD) are not well characterized and may reveal indicators associated with asymptomatic stages of AD.
Methods: This retrospective observational study compared 246 Anti-Amyloid Treatment in Asymptomatic AD study (A4) individuals who met elevated brain amyloid eligibility criteria to 121 individuals in the companion Longitudinal Evaluation of Amyloid Risk and Neurodegeneration study (LEARN) who were eligible for A4 except did not meet elevated amyloid eligibility criteria. Matched-controls for A4/LEARN, using a 3:1 match of demographics, Medicare enrollment month, and frailty status, were randomly selected from Medicare beneficiaries without cognitive impairment/dementia claims.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!