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Cytotoxic effects of the standardized extract from Salisb. rhizomes via induction of mitochondria-mediated caspase-dependent apoptotic pathway and p21-mediated G0/G1 cell cycle arrest on human gastric cancer AGS cells.
J Toxicol Environ Health A
March 2025
Department of Animal Biotechnology, Institute of Tropical Biology, Vietnam Academy of Science and Technology, Ho Chi Minh, Vietnam.
Article Synopsis
- Salisb. is a traditional herb used to treat various diseases, including gastric cancer, but its specific effects on gastric cancer cells require further investigation.
- This study explored how a standardized extract of Salisb. rhizome induces cell death in gastric cancer AGS cells, primarily through apoptosis and cell cycle disruption.
- The extract's active compounds, curdione and germacrone, were shown to affect mitochondrial function and cell cycle regulatory proteins, highlighting their potential as anti-cancer agents.
Small Molecules for the Treatment of Long-COVID-Related Vascular Damage and Abnormal Blood Clotting: A Patent-Based Appraisal.
Viruses
March 2024
ARESS Puglia-Agenzia Regionale Strategica per la Salute ed il Sociale, I-70121 Bari, Italy.
Article Synopsis
- COVID-19 can lead to serious complications like abnormal blood clotting and heart issues, prompting the use of treatments such as antiplatelet and anticoagulant medications, though their effectiveness remains uncertain.
- Researchers are also exploring anti-inflammatory drugs to combat the immune dysregulation associated with severe COVID-19 symptoms, often referred to as the cytokine storm.
- Recent patent literature highlights small molecules that could address long-COVID-related complications, focusing on the potential of ramatroban, emricasan, rimeporide, and natural polyphenolic compounds as therapeutic options.
Lethal Caspase-1/4-Dependent Injury Occurs in the First Minutes of Coronary Reperfusion and Requires Calpain Activity.
Int J Mol Sci
February 2023
Department of Physiology and Cell Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
To study the relationship between caspase-1/4 and reperfusion injury, we measured infarct size (IS) in isolated mouse hearts undergoing 50 min global ischemia/2 h reperfusion. Starting VRT-043198 (VRT) at reperfusion halved IS. The pan-caspase inhibitor emricasan duplicated VRT's protection.
View Article and Find Full Text PDFFerrostatin-1 and Z-VAD-FMK potentially attenuated Iron-mediated neurotoxicity and rescued cognitive function in Iron-overloaded rats.
Life Sci
January 2023
Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, 50200, Thailand; Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address:
Aims: The present study was aimed to investigate the effects of cell death inhibitors including ferroptosis inhibitor, ferrostatin-1 (FER-1) and a pan-caspase inhibitor, z-VAD-FMK on brain parameters and cognitive function in iron-overloaded rats.
Main Methods: Male Wistar rats (n = 30) were divided into 2 groups to receive an intraperitoneal injection with either 10 % dextrose in normal saline solution (NSS) (control group, n = 6) or 100 mg/kg iron dextran (Fe group, n = 24) for 6 weeks. After 4 weeks of injection, Fe-injected rats were subdivided into 4 subgroups (n = 6/subgroup) to subcutaneously receive with 1) vehicle (10 % DMSO in NSS), 2) deferoxamine (25 mg/kg), 3) FER-1 (2 mg/kg), or 4) z-VAD-FMK (1 mg/kg).
Complement factor D derived from epicardial adipose tissue participates in cardiomyocyte apoptosis after myocardial infarction by mediating PARP-1 activity.
Cell Signal
January 2023
Department of Cardiac Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Background: Acute myocardial infarction (MI) is considered to be the main cause of congestive heart failure. The aim of this study was to provide an in-depth analysis of athophysiological processes and provide key targets for intervention in the occurrence of acute MI.
Methods: A rat model of MI was established by ligation of left anterior descending branch.
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