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Disparities in screening and risk stratification for hispanic adults with metabolic dysfunction-associated steatotic liver disease.
Hepatology
October 2024
MASLD Research Center, Division of Gastroenterology and Hepatology, University of California at San Diego, La Jolla, CA 92103, United States.
Background Aims: Cut-points for non-invasive tests (NITs) for risk stratification in metabolic dysfunction-associated steatotic liver disease (MASLD) were derived from predominantly non-Hispanic populations. It is unknown if these cut-points perform adequately in Hispanic individuals. We assessed the performance characteristics of current NIT cut-points among Hispanic patients and determined whether they could be further optimized.
View Article and Find Full Text PDFIntroduction of a nationwide first-trimester anomaly scan in the Dutch national screening program.
Am J Obstet Gynecol
July 2024
Department of Obstetrics and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:
Article Synopsis
- A study in the Netherlands evaluated the effectiveness of first-trimester anomaly scans to detect fetal structural defects in pregnant women as part of a nationwide prenatal screening program from November 2021 to November 2022.
- The study found that 74.9% of eligible women opted for the scan, and among those, 1.0% were flagged for potential anomalies while 54.9% of those cases were confirmed with abnormal findings in follow-up scans.
- The results highlighted the types of anomalies identified, including 332 structural and 117 genetic anomalies, indicating the scan's usefulness for early decision-making regarding reproductive options.
Preincubation-dependent inhibition of organic anion transporting polypeptide 2B1.
Eur J Pharm Sci
September 2024
Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland. Electronic address:
Preincubation with inhibitor in organic anion transporting polypeptide (OATP) in vitro assays may increase the inhibition potency of inhibitors compared to conventional inhibition assays with only short inhibitor coincubation with substrate. The decrease in IC may affect prediction of drug-drug interactions (DDI) involving these transporters and inhibitors. Only few drugs, however, have been assessed for the preincubation-dependent inhibition of the OATP2B1 transporter.
View Article and Find Full Text PDFPrognosis and distribution of ischemic stroke with negative diffusion-weighted imaging: a systematic review and meta-analysis.
Front Neurol
April 2024
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
Background: Magnetic resonance diffusion-weighted imaging (DWI) is the most sensitive modality for ischemic stroke diagnosis. However, DWI may fail to detect ischemic lesions in a proportion of patients.
Methods: Following PRISMA statement, a systematic search of Medline, Embase, and Web of Science was conducted until January 3, 2024.
Psychometric Validation of a Hearing Screening Questionnaire for Preschoolers Based on Language Development Evaluation by Caregivers.
Folia Phoniatr Logop
April 2024
UMR INSERM 1107, Neurosensory Biophysics, School of Medicine, Université Clermont Auvergne, Clermont-Ferrand, France.
Introduction: This study aimed to validate three age-adjusted versions of a Hearing Screening Questionnaire for Preschoolers, in Brazilian Portuguese, based on parents' perception of their children's hearing and oral language.
Methods: Psychometric validation was conducted on three questionnaires, each comprising nine items with yes/no responses. Three items focused on hearing screening at birth, and six assessed hearing and oral language.
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