AI Article Synopsis
- The study assessed how a tiered morphological approach can detect developmental neurotoxicity in rat offspring treated with methylazoxymethanol (MAM) during pregnancy.
- The approach involved measuring various morphometric parameters and showed significant effects at different levels, from overall brain size to specific neuron loss in the hippocampus, while cerebellar neurons remained unaffected.
- The results demonstrated that as researchers progressed through the tiers (from basic size measurements to detailed neuron evaluation), they could better identify the extent and specific locations of brain damage.
Article Abstract
To evaluate the ability of a tiered quantitative morphological approach to reveal developmental neurotoxicity, morphometric parameters were measured in the offspring of rats treated with methylazoxymethanol (MAM) during days 13-15 of pregnancy. Treatment was aimed at inhibiting the proliferation phase of hippocampal neurons while leaving cerebellar neurons unaffected. 2D and 3D assessment of brain morphology combined with straightforward measurement of brain size, weight and volume, and the usefulness of estimation of total neuron numbers were studied. Each tier indicated major effects of MAM, from macroscopic effects in the cerebrum (first tier) to a considerable loss of neurons in the hippocampal CA1 pyramidal layer (third tier). The cerebellum and the number of cerebellar granular neurons were not changed. Along with each step of the proposed tiered approach (brain size-->linear morphometry-->stereology), the discriminative strength of the endpoints, and thus the probability to pinpoint the extent and location of developmental brain lesions increased.
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| http://dx.doi.org/10.1016/j.reprotox.2005.04.006 | DOI Listing |
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