Carbohydr Res
Laboratoire de Chimie Organique II-Glycochimie, Unité Mixte de Recherche CNRS 5181, Université Lyon 1, Chimie Physique Electronique de Lyon, 43 Boulevard du 11 Novembre 1918, F-69622 Villeurbanne, France.
Published: August 2005
This paper deals with new approaches to alpha-Neu5NAc-(2,6)-D-GalN3 building blocks, suitable as glycosylation donors. The major improvement, by comparison with the results of the literature, lies in the glycosylation step of a new d-galactosamine acceptor (tert-butyldimethylsilyl 3-O-acetyl-2-azido-2-deoxy-beta-D-galactopyranoside) with O-methyl-S-[methyl(5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosyl)onate] dithiocarbonate as the N-acetylneuraminic acid donor. The reaction affords the expected disaccharide in high yield (85%) and a complete alpha-Neu5NAc stereoselectivity. A subsequent oxidation step, eliminating the glycal by-product allows an easier purification. Afterwards, the tert-butyldimethylsilyl disaccharide can be transformed into a donor, after cleavage of the anomeric group in smooth conditions.
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http://dx.doi.org/10.1016/j.carres.2005.05.007 | DOI Listing |
Res Social Adm Pharm
January 2025
Institute of Health Policy, Management and Evaluation, University of Toronto, 155 College Street, Suite 425, Toronto, Ontario, M5T 3M6, Canada; Research & Innovation, North York General Hospital, 4001 Leslie Street, Toronto, Ontario, M2K 1E1, Canada.
Purpose: Diversion or theft of controlled substances is a recognized problem affecting healthcare systems globally. The purpose of this study was to develop a framework for identifying and characterizing system factors leading to vulnerabilities for diversion within hospitals.
Methods: We applied a qualitative framework method, which involved 1) compiling a list of critical diversion vulnerabilities through observations and proactive risk analyses in the inpatient pharmacy, emergency department and intensive care unit of two Canadian hospitals; 2) coding the vulnerabilities into deductively and inductively derived themes and subthemes; and 3) building a conceptual framework.
Vet Clin North Am Exot Anim Pract
January 2025
Avian and Exotic Pet Service, UQ Veterinary Medical Centre, Building 8156, Main Drive, University of Qld, Gatton, Queensland 4343, Australia. Electronic address:
Imaging of an exotic animal with gastroenteric disease is often essential to make a diagnosis. The selection of a modality and its effective use needs careful consideration in each case. Obtaining a high-quality image and its interpretation are an acquired skill.
View Article and Find Full Text PDFEnviron Res
January 2025
Department of Civil, Environmental, & Architectural Engineering, Worcester Polytechnic Institute, Worcester, MA, United States. Electronic address:
The growing impact of climate change and escalating wildfire seasons has led to heightened ambient air pollution, potentially affecting children's sleep health. However, current epidemiological research often relies on outdoor weather data to model the environmental impacts on sleep health, potentially mischaracterizing the actual bedroom environment. To address these challenges, we conducted experiments to investigate the relationships among ambient, indoor, and personal exposure to PM concentrations and obstructive sleep apnea (OSA) in children.
View Article and Find Full Text PDFSpine J
January 2025
Department of Orthopaedic Surgery, University of California, San Francisco.
Background Context: There are a number of risk factors- from biological, psychological, and social domains- for non-specific chronic low back pain (cLBP). Many cLBP treatments target risk factors on the assumption that the targeted factor is not just associated with cLBP but is also a cause (i.e, a causal risk factor).
View Article and Find Full Text PDFSci Total Environ
January 2025
Key Laboratory of Cryospheric Science and Frozen Soil Engineering, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China.
The inadequacy of current emission reduction measures necessitates exploring innovative approaches to address the critical issue of ice sheet and mountain glacier melting. Geoengineering emerges as a potential solution to mitigate severe cryospheric changes. This review systematically examines geoengineering techniques tailored to ice sheets and mountain glaciers, analyzing their efficacy, risks, and limitations based on existing literature.
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