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Genetic factors associated with patient-specific warfarin dose in ethnic Indonesians.
BMC Med Genet
June 2011
Mochtar Riady Institute for Nanotechnology, Tangerang, Indonesia.
Background: CYP2C9 and VKORC1 are two major genetic factors associated with inter-individual variability in warfarin dose. Additionally, genes in the warfarin metabolism pathway have also been associated with dose variance. We analyzed Single Nucleotide Polymorphisms (SNPs) in these genes to identify genetic factors that might confer warfarin sensitivity in Indonesian patients.
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