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Dual-emissive Eu(III)-functionalized metal-organic frameworks for visual, rapid, and intelligent sensing of albendazole and albendazole sulfoxide in animal-origin food.
Anal Chim Acta
February 2024
National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Key Laboratory of Industrial Microbiology, School of Food and Biological Engineering, Hubei University of Technology, Wuhan, 430068, China. Electronic address:
Article Synopsis
- - Albendazole (ABZ) is commonly used to treat parasitic infections in animals, but its overuse can lead to harmful drug residues in food and resistance, posing risks to human health.
- - A new dual-emission europium fluorescent sensor (EuUHC-30) has been developed to detect ABZ and its toxic metabolite, albendazole sulfoxide (ABZSO), with high sensitivity and low detection limits.
- - This sensor can be used to quantify ABZ and ABZSO in animal-derived food such as milk and pig kidney and includes a smartphone-assisted feature for practical application, offering a quick and effective detection method.
Development and validation of stability indicating UPLC methods for related substances and assay analyses of ricobendazole hydrochloride.
J Pharm Biomed Anal
January 2024
Department of Analytical Chemistry, Faculty of Pharmacy, Marmara University, İstanbul, Türkiye; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, İstanbul, Türkiye. Electronic address:
Ricobendazole hydrochloride is an active ingredient of a veterinary antiparasitic drug. The aim of this study was to investigate the degradation of ricobendazole hydrochloride under stress and stability testing conditions, for which we developed and validated the first stability indicating, specific, precise, accurate, and robust assay and related substances UPLC methods. The Acquity UPLC BEH C column was used for the related substances and assay analyses of ricobendazole hydrochloride, and the analyses were performed at 25 °C sample and 30 °C column temperatures with a 2 µL injection volume.
View Article and Find Full Text PDFComprehensive stability study of benzimidazole drug residues in standard solution, muscle and milk.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
April 2023
Doping Control Laboratory, Department of Pharmacology, Istanbul Pendik Veterinary Control Institute, Istanbul, Türkiye.
The performance criteria of analytical methods and the necessity for stability analysis to provide the accuracy of the results of the analyzed samples are explained in European Commission Decision 2021/808/EC and the guidance document SANTE/2021/11312. Detection of time-dependent changes in drug concentrations during storage or transport and re-analysis of samples are crucial to obtain high-quality results and reliable data. In this way, it allows toxicologists to interpret the analytical results accurately in drug analyses.
View Article and Find Full Text PDFHighly sensitive electro-oxidative voltammetric determination of anthelmintic drug albendazole using porous graphitic carbon nitride sensor infused with cationic micellar solution.
J Pharm Biomed Anal
November 2022
Department of Chemistry, School of Advanced Sciences, KLE Technological University, Hubballi 580031. Karnataka, India. Electronic address:
A sensitive and novel electrochemical senser, acetyl trimethylammonium bromide (CTAB)-immobilized nitrogen rich g-CN nanosheet modified carbon paste electrode was developed, for the electrochemical investigation of the anthelmintic drug Albendazole (ABZ) using voltammetric tools like cyclic and square wave voltammetry. The results showed that the modified carbon paste electrode exhibited remarkable electro-catalytic action towards the electrochemical oxidation of ABZ in a phosphate buffer solution at pH 3 compared to bare carbon paste electrode. The electrode material was characterized by CV, scanning electron microscopy (SEM), atomic force microscope (AFM), and electrochemical impedance spectroscopy (EIS).
View Article and Find Full Text PDFMulti-residue methodology for quantification of antiparasitics in hen eggs by LC-MS/MS: development, validation and application to 348 samples from Brazil.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
August 2022
Instituto de Química, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Analytical methodology for quantification of 15 antiparasitic drugs and their respective metabolites in laying hen eggs was optimized and validated. The method uses acetonitrile as solvent extraction, sodium chloride for salting-out, low-temperature purification and analysis by LC-MS/MS. A total of 348 egg samples were collected in 11 states of Brazil and 50% of the total samples presented antiparasitic residues, which were albendazole, fipronil, fenbendazole, ivermectin, oxibendazole and mebendazole.
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