AI Article Synopsis
- A cyclic phosphoric acid derivative from (R)-BINOL acted as a chiral Brønsted acid at a concentration of 10 mol %.
- The compound facilitated the hydrophosphonylation process of aldimines using diisopropyl phosphite at room temperature.
- The resulting alpha-amino phosphonates exhibited good to high enantioselectivity.
Article Abstract
[reaction: see text] A cyclic phosphoric acid derivative, derived from (R)-BINOL, was used as a chiral Brønsted acid (10 mol %) in hydrophosphonylation of aldimines with diisopropyl phosphite at room temperature. Alpha-amino phosphonates were obtained with good to high enantioselectivities.
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| http://dx.doi.org/10.1021/ol050695e | DOI Listing |
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