In this work we demonstrate the self-assembly of beta-D glucose-protected Pt nanocrystals (average particle size = 4.1 nm) into nanowire-like assemblies under ambient conditions.
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http://dx.doi.org/10.1039/b502342d | DOI Listing |
Nano Lett
November 2024
Department of Chemistry, New York University, New York, New York 10003, United States.
Artificially expanded genetic information systems (AEGIS) were developed to expand the diversity and functionality of biological systems. Recent experiments have shown that these expanded DNA molecular systems are robust platforms for information storage and retrieval as well as useful for basic biotechnologies. In tandem, nucleic acid nanotechnology has seen the use of information-based "semantomorphic" encoding to drive the self-assembly of a vast array of supramolecular devices.
View Article and Find Full Text PDFBioconjug Chem
August 2024
University Grenoble Alpes, Grenoble 38000, France.
Glycoamphiphiles have attracted considerable interest in a broad range of application fields owing to their solution and bulk-state self-assembly abilities. Despite their importance, the straightforward synthesis of glycoamphiphiles consisting of a hydrophilic carbohydrate linked to a hydrophobic aglycone remains one of the major challenges in glycosciences. Here, a rapid, simple, and efficient synthetic access to chemically stable glycoamphiphiles at physiological pH, namely, -(β-d-glycosyl)-2-alkylbenzamide, is reported.
View Article and Find Full Text PDFBiophys J
July 2024
School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, Georgia. Electronic address:
Reactions that occur within the lipid membrane involve, at minimum, ternary complexes among the enzyme, substrate, and lipid. For many systems, the impact of the lipid in regulating activity or oligomerization state is poorly understood. Here, we used small-angle neutron scattering (SANS) to structurally characterize an intramembrane aspartyl protease (IAP), a class of membrane-bound enzymes that use membrane-embedded aspartate residues to hydrolyze transmembrane segments of biologically relevant substrates.
View Article and Find Full Text PDFMed Oncol
May 2024
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Because of the high biocompatibility, self-assembly capability, and CD71-mediated endocytosis, using human heavy chain ferritin (HFn) as a nanocarrier would greatly increase therapeutic effectiveness and reduce possible adverse events. Anti-PD-L1 siRNA can downregulate the level of PD-L1 on tumor cells, resulting in the activation of effector T cells against leukemia. Therefore, this study aimed to produce the tumor-targeting siPD-L1/HFn nanocarrier.
View Article and Find Full Text PDFInt J Nanomedicine
December 2023
School of Traditional Chinese Pharmacy, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, People's Republic of China.
Purpose: Enhancing the dissolution, permeation and absorption of active components with low solubility and poor permeability is crucial for maximizing therapeutic efficacy and optimizing functionality. The objective of this study is to investigate the potential of natural polysaccharides as carriers to improve the biopharmaceutical properties of active components.
Methods: In this study, we employed four representative flavonoids in Astragali Radix, namely Calycosinglucoside (CAG), Ononin (ON), Calycosin (CA) and Formononetin (FMN), as a demonstration to evaluate the potential of Astragalus polysaccharides (APS) as carriers to improve the biopharmaceutical properties, sush as solubility, permeability, and absorption in vivo.
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