The etiology of transient erythroblastopenia of childhood (TEC) remains unknown, although an association with viral infections has been proposed. The authors describe a 3.5-year-old girl with classic TEC concomitantly with human parvovirus B19 (HPV) infection. The infection was evident by detection of HPV genome in the blood and the bone marrow by polymerase chain reaction. Viral genome was no longer detected when the TEC resolved clinically. The patient was immunocompetent and the anemia has not recurred. To the authors' knowledge, this is one of the few documented cases of classic TEC attributable to HPV infection.
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Transient erythroblastopenia of childhood after COVID-19 infection: a case report.
Ital J Pediatr
July 2024
Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Via Luigi De Crecchio, Naples, 80138, Italy.
Article Synopsis
- Transient erythroblastopenia of childhood (TEC) is a rare condition affecting children, typically linked to viral and immune factors, and has now been associated with COVID-19.
- A case is presented of a child with severe red blood cell depletion and absent erythroblasts in the bone marrow after a SARS-CoV-2 infection, showing signs similar to a known severe immune disorder (HLH).
- The report suggests that COVID-19 can induce TEC and emphasizes the need to include it in assessments of patients with unexplained red blood cell production issues, considering its relation to diseases like MIS-C.
Etiologies and Outcomes of Normocytic Anemia in Children.
J Pediatr
August 2024
Division of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX; Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX.
Objective: To characterize the evaluation and outcomes of children referred to pediatric hematology for normocytic anemia.
Study Design: Retrospective cohort study of children aged 0-21 years referred to a tertiary pediatric hematology clinic for normocytic anemia from 2019 through 2021. Normocytic anemia was defined as a low hemoglobin and normal mean corpuscular volume, per the referring laboratory reference range.
[A child with persistent anaemia].
Tidsskr Nor Laegeforen
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Background: Anemia in children is common and finding the underlying cause is often uncomplicated. However, in some cases, the underlying diagnosis is rare and difficult to diagnose.
Case Presentation: A toddler presented with severe anemia with normal red cell indices and a low reticulocyte count.
Transient erythroblastopenia of childhood is a rare, benign, self-limited condition seen in infants and young children. Laboratory studies will show moderate or severe normochromic normocytic anemia accompanied by absent or low reticulocytes, neutropenia, and mild thrombocytosis or thrombocytopenia. The etiology is unclear, but it has been associated with clinical or laboratory evidence of a recent viral syndrome.
View Article and Find Full Text PDFTransient erythroblastopenia due to a GATA1 variant in an infant female.
Pediatr Blood Cancer
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Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Diamond-Blackfan anemia (DBA) is a congenital anemia with erythroid cell aplasia. Most of the causative genes are ribosomal proteins. GATA1, a hematopoietic master transcription factor required for erythropoiesis, also causes DBA.
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