This month's column presents a case study of a Muslim patient and the considerations for culturally sensitive care that one nurse implemented. The interventions resolved potential cultural conflict and involved several departments within her agency. A brief review of the deliberations and decisions of the Institutional Ethics Committee identifies the supporting ethical arguments and the recommendations for developing cultural sensitivity within its healthcare organizations.
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http://dx.doi.org/10.1097/00004045-200506000-00004 | DOI Listing |
J Cell Mol Med
February 2025
Department of Chemotherapy, Jiangxi Cancer Hospital, Nanchang, Jiangxi, China.
Tumour cells possess a multitude of chemoresistance mechanisms, which could plausibly contribute to the ineffectiveness of chemotherapy. O-methylguanine-DNA methyltransferase (MGMT) is an important effector protein associated with Temozolomide (TMZ) resistance in various tumours. To some extent, the expression level of MGMT determines the sensitivity of cells to TMZ, but the mechanism of its expression regulation has not been fully elucidated.
View Article and Find Full Text PDFJ Liposome Res
January 2025
School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, Guangdong, China.
This study aimed to design a novel liposome containing GA modified phosphatidylcholine lipid (GA-PC Lip) and determine its susceptibility to tumor over-expressed secretory phospholipase A (sPLA) and its anti-cancer effect compared to conventional liposomes (Convention Lip). The liposomes were characterized for size, drug loading, encapsulation efficiency, and stability. A 6-CF release assay was conducted to assess the sensitivity of the liposomes to the tumor-overexpressed secretory phospholipase A (sPLA).
View Article and Find Full Text PDFAust Vet J
January 2025
Scone Equine Hospital, 406 Bunnan Road, Scone, New South Wales, Australia.
Introduction: Sepsis is a leading cause of morbidity and mortality in neonatal foals. Administration of appropriate antimicrobials and early aggressive supportive treatment is central to the efficacious treatment of neonatal sepsis and has proven to positively influence outcomes. The primary aim of our study was to evaluate microorganism results and antimicrobial sensitivities of neonatal foals with a positive blood culture submitted to our intensive care unit (ICU) during 2005-2022.
View Article and Find Full Text PDFJ Adv Nurs
January 2025
College of Nursing, Guangzhou Medical University, Guangzhou, Guangdong, China.
Aims: To translate the Supportive and Palliative Care Indicators Tool (SPICT) into Chinese and conduct preliminarily tests of its performance in hospitalized patients with cancer.
Design: A cross-sectional validation study conducted from January to March 2024.
Methods: SPICT 2022 was translated in both directions, following the Brislin translation model, and the Chinese version culturally debugged through expert consultation and pre-testing.
Front Cell Infect Microbiol
January 2025
Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Introduction: Invasive pulmonary aspergillosis (IPA) increases the risk of mortality of critically ill patients. Diagnostic criteria specifically targeting patients in intensive care units(ICUs) have been developed to improve diagnostic sensitivity. This study investigated health outcomes among patients in ICUs with Aspergillus isolates identified using bronchoscopy.
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