AI Article Synopsis
- The conceptus-endometrium interaction during early pregnancy involves important molecules like cytokines and hormones, particularly the suppressor of cytokine signaling (SOCS) proteins.
- There was a notable increase in SOCS transcripts in pregnant ewes, with distinct patterns based on whether they were unilaterally pregnant or not.
- When cyclic ewes received an injection of recombinant ovine interferon tau (IFNtau), it stimulated SOCS mRNA expression, indicating that SOCS proteins might play a role in negatively regulating the IFNtau signaling pathway.
Article Abstract
It is established that the conceptus-endometrium dialogue involves cytokines, growth factors and hormones. Given the crucial functions of the suppressor of cytokine signaling (SOCS) family proteins in cytokine signalling, we analyzed the expression and the regulation of CIS and SOCSs 1-3 transcripts during early pregnancy in the ovine endometrium. An overall stimulation of the SOCS transcripts was described in the pregnant ewes with two specific patterns. Unilaterally pregnant ewes confirmed the conceptus-produced factors as regulators of the SOCSs 1-3 expression at day 16 of pregnancy. Intrauterine injection of recombinant ovine interferon tau (IFNtau) in cyclic ewes stimulated the expression of the SOCS mRNA with various potencies, therefore suggesting that the SOCS could take part in the negative regulation of the IFNtau signalling pathway.
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| http://dx.doi.org/10.1677/jme.1.01667 | DOI Listing |
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