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Paradoxical Pro-angiogenic Effect of Low-Dose Ellipticine Identified by In Silico Drug Repurposing.
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Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, Seong-nam 13496, Korea.
Inadequate vessel maintenance or growth causes ischemia in diseases such as myocardial infarction, stroke, and neurodegenerative disorders. Therefore, developing an effective strategy to salvage ischemic tissues using a novel compound is urgent. Drug repurposing has become a widely used method that can make drug discovery more efficient and less expensive.
View Article and Find Full Text PDFExploiting ensemble learning to improve prediction of phospholipidosis inducing potential.
J Theor Biol
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Department of Biochemistry, Pt. Jawahar Lal Nehru Memorial Medical College, Raipur 492001, India.
Phospholipidosis is characterized by the presence of excessive accumulation of phospholipids in different tissue types (lungs, liver, eyes, kidneys etc.) caused by cationic amphiphilic drugs. Electron microscopy analysis has revealed the presence of lamellar inclusion bodies as the hallmark of phospholipidosis.
View Article and Find Full Text PDFNovel Salicylic Acid Analogs Induce a Potent Defense Response in Arabidopsis.
Int J Mol Sci
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Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA.
The master regulator of salicylic acid (SA)-mediated plant defense, NPR1 (NONEXPRESSER OF PR GENES 1) and its paralogs NPR3 and NPR4, act as SA receptors. After the perception of a pathogen, plant cells produce SA in the chloroplast. In the presence of SA, NPR1 protein is reduced from oligomers to monomers, and translocated into the nucleus.
View Article and Find Full Text PDFXeronine structure and function: computational comparative mastery of its mystery.
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Biochemical Pharmacology and Toxicology Unit, Department of Biochemistry, Federal University of Technology, PMB 704 Akure, Nigeria.
(Noni) fruit has a long history of dietary use in tropical regions of the world. Pharmacological properties that have been attributed to the fruit include anti-inflammatory, anti-cancer, and antioxidant properties. Xeronine, a small alkaloid which has been patented (US4543212) is one of the bioactive compounds of Noni fruit, which is believed to be capable of modifying the molecular structure of specific inactive proteins thereby regulating proper folding to active enzymes.
View Article and Find Full Text PDFInteraction Studies of Withania Somnifera's Key Metabolite Withaferin A with Different Receptors Assoociated with Cardiovascular Disease.
Curr Comput Aided Drug Des
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Department of Biotechnology, Rajalakshmi Engineering College, Chennai -602105, India.
Withania somnifera commonly known as Ashwagandha in India is used in many herbal formulations to treat various cardiovascular diseases. The key metabolite of this plant, Withaferin A was analyzed for its molecular mechanism through docking studies on different targets of cardiovascular disease. Six receptor proteins associated with cardiovascular disease were selected and interaction studies were performed with Withaferin A using AutoDock Vina.
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