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Pharmaceutical technological trends containing flavonoids: a patent review.
Future Med Chem
January 2025
Postgraduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão, Brazil.
Flavonoids such as silibinin, hesperetin, and phloretin exhibit well-documented biological activities, including anti-inflammatory, cytoprotective, anticarcinogenic, and antioxidant effects. However, their clinical application remains limited due to challenges such as poor aqueous solubility, low bioavailability, and restricted intestinal absorption, which can significantly reduce their pharmacological efficacy. This review analyzed patents related to innovative pharmaceutical technologies for flavonoids.
View Article and Find Full Text PDFDistribution of different forms of metal ions in Antarctic krill (Euphausia superba) oil: A mechanism of their pro-oxidant effects relating to association colloids.
Food Chem
January 2025
School of Food Science and Engineering, Hainan University, Haikou 570228, China.
Due to the fact that association colloids were formed in krill oil, the oxidation mechanism of krill oil was more complicated. In this study, water-soluble ferrous sulfate (Fe(SO)), oil-soluble ferrous fumarate (CHFeO) and insoluble ferric oxide (FeO) were added to krill oil and stored at 60 °C for accelerated oxidation. Peroxide value, thiobarbituric acid reactive substances and aldehyde content showed that Fe(SO) had a stronger pro-oxidative effect.
View Article and Find Full Text PDFStability of probiotic microcapsules produced through complex coacervation based on whey protein-gum arabic coupled with double emulsification: Role of krill oil in middle oil phase.
Int J Biol Macromol
January 2025
Sericultural and Agrifood Res Inst, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China.
The objective of this study was to prepare a microcapsule system composed of the inner microenvironment (probiotics), middle oil layer (soybean oil and polyglycerol polyricinoleate) and outer coacervate (whey protein and gum arabic) using double emulsification technique coupled with complex coacervation to encapsulate probiotics, and to evaluate the effect of adding krill oil (KO) to the middle oil layer on microcapsule structure and probiotic stability. The results of Fourier transform infrared spectroscopy and Scanning electron microscopy confirmed that whey protein may capture phospholipids in KO through hydrogen bonds, resulting in the formation of a more compact coacervate. Due to the compact coacervate enhanced the vapor transport barrier and reduced water evaporation during low-temperature dehydration, probiotics encapsulated in KO-supplemented microcapsules revealed less cell damage and a higher survival rate after freeze-drying.
View Article and Find Full Text PDFA novel supramolecular nanodrugs for improving the cognitive function of schizophrenia by protecting active lactone of arecoline.
Biomed Pharmacother
January 2025
School of Pharmaceutical Sciences, Institute of Materia Medica, Xinjiang University, Urumqi 830017, China. Electronic address:
Over 30 % of patients with schizophrenia experience treatment resistance and severe side effects. The limited efficacy of antipsychotic therapies poses a challenge, partly due to the blood-brain barrier (BBB) and the non-selective targeting of these drugs. Herein, we report on arecoline (ARE), a water soluble natural small molecule, which was successfully constructed a phospholipid complex by noncovalent interactions.
View Article and Find Full Text PDFEffect of Lipid Composition and Stirring Dynamics on Oxygen Microbubble Stability and Oxygen Release.
Langmuir
January 2025
Biomedical Engineering Program, University of Colorado Boulder, Boulder, Colorado 80309, United States.
Lipid-coated oxygen microbubbles (OMBs) are being investigated for biomedical applications to alleviate hypoxia such as systemic oxygenation and image-guided radiosensitization therapy. Additionally, they hold potential for boarder application as oxygen carriers beyond the biomedical filed. Understanding the stability and oxygen release properties of OMBs in dynamic aqueous environments is critical for these applications.
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