Introduction: Super Slick (TP Orthodontics, LaPorte, Ind), a polymeric-coated ligature, has recently been introduced to the orthodontic market. The manufacturer claims it will significantly reduce friction. The purposes of this study were to determine whether Super Slick modules show lower friction than round and rectangular modules and to put the frictional forces into perspective with a self-ligating bracket.
Methods: Maxillary premolar, stainless steel, self-ligating, and monocrystalline brackets with .022-in slots were used with straight lengths of .018-in and .019 x .025-in stainless steel wires. Buccal segment models were set up with 1 molar band and 2 premolar brackets for each test group: self-ligating brackets with the slide closed, self-ligating brackets with the slide open, and monocrystalline brackets. The latter 2 groups were tested with all 3 types of elastomeric module. Each setup was tested both under dry conditions and after soaking in a water bath for 1 hour.
Results: The self-ligating brackets demonstrated virtually zero friction with each combination of wire and environmental condition. When the different bracket and elastomeric module combinations were compared, significant differences were observed. In all but 2 combinations, round modules provided the least resistance to sliding and rectangular modules the greatest, with Super Slick modules in between the 2. The self-ligating bracket provided the least resistance to sliding of all the bracket/ligation combinations and almost entirely eliminated friction under the conditions of this experiment.
Conclusions: Super Slick modules demonstrated greater resistance to sliding than conventional round modules, but not rectangular. Self-ligating brackets provided the least resistance to sliding of all bracket/ligation combinations and were the only method that almost entirely eliminated friction. The .018-in and .019 x .025-in wires exhibited similar friction in the dry state, but, when wet, the .018-in wire produced less friction. Ceramic brackets demonstrated greater resistance to sliding than stainless steel brackets. Lubrication reduced the friction with .018-in wires and increased it for .019 x .025-in wires.
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http://dx.doi.org/10.1016/j.ajodo.2004.01.025 | DOI Listing |
Unlabelled: Antibiotic resistance is a global crisis that stems from the use of antibiotics as an essential part of modern medicine. Understanding how antibiotic resistance is controlled among cells in bacterial populations will provide insights into how antibiotics shape microbial communities. Here, we describe patterns of gene expression that arise from growth on a surface either in isolation or under subinhibitory chloramphenicol exposure.
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Eötvös Loránd University, Department of Physics of Complex Systems, Budapest, Hungary.
Patients with High-Grade Serous Ovarian Cancer (HGSOC) exhibit varied responses to treatment, with 20-30% showing de novo resistance to platinum-based chemotherapy. While hematoxylin-eosin (H&E)-stained pathological slides are used for routine diagnosis of cancer type, they may also contain diagnostically useful information about treatment response. Our study demonstrates that combining H&E-stained whole slide images (WSIs) with proteomic signatures using a multimodal deep learning framework significantly improves the prediction of platinum response in both discovery and validation cohorts.
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January 2025
School of Aerospace Engineering, Xi'an Jiaotong University, West Xianning Road 28, Xi'an 710049, China.
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School of Mechanical Engineering, University of Jinan, Jinan 250022, China.
This research centers around cast steel 20Mn, which is the material utilized for the ear-picking roller of a corn harvester. The study delves into methods of enhancing its hydrophobicity and wear resistance. Fiber laser-processing technology was employed to fabricate pangolin bionic micro-textures on the material surface, and PVD technology was utilized to deposit a TiN coating.
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Department of Molecular Microbiology, John Innes Centre, Norwich, UK.
Examples of long-range gene regulation in bacteria are rare and generally thought to involve DNA looping. Here, using a combination of biophysical approaches including X-ray crystallography and single-molecule analysis for the KorB-KorA system in Escherichia coli, we show that long-range gene silencing on the plasmid RK2, a source of multi-drug resistance across diverse Gram-negative bacteria, is achieved cooperatively by a DNA-sliding clamp, KorB, and a clamp-locking protein, KorA. We show that KorB is a CTPase clamp that can entrap and slide along DNA to reach distal target promoters up to 1.
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