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Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissues.
Nat Commun
January 2025
MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, China.
Visualizing mechanical stress distribution in soft and live biomaterials is essential for understanding biological processes and improving material design. However, it remains challenging due to their complexity, dynamic nature, and sensitivity requirements, necessitating innovative techniques. Since polysaccharides are common in various biomaterials, a biosensor integrating a Förster resonance energy transfer (FRET)-based tension sensor module and carbohydrate-binding modules (FTSM-CBM) has been designed for real-time monitoring of the stress distribution of these biomaterials.
View Article and Find Full Text PDFA ratiometric fluorescent probe for sensitively tracking peroxynitrite during drug-induced hepatotoxicity.
Chembiochem
January 2025
Xinzhou Normal University, Department of Chemistry, CHINA.
As one of the essential components of reactive oxygen species (ROS), peroxynitrite (ONOO-) plays an indispensable role in redox homeostasis and signal transduction processes, and its deviant levels are associated with numerous clinical diseases. Therefore, accurate and rapid detection of intracellular ONOO- levels is crucial for revealing its role in physiological and pathological processes. Herein, we constructed a ratiometric fluorescent probe to detect ONOO- levels in biological systems.
View Article and Find Full Text PDFBackground-free luminescent and chromatic assay for strong visual detection of creatinine.
Talanta
January 2025
Key Laboratory of Photovoltaic and Energy Conservation Materials, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China. Electronic address:
Creatinine is an essential biomarker for the clinical diagnosis and treatment of renal insufficiency. Although fluorescent methods are powerful tools for creatinine detection, almost all reported fluorescent probes rely on short-wavelength excitation and a single fluorescent signal, making them susceptible to environmental and operational conditions. In this study, a near-infrared excited, highly sensitive, and multi-output signal sensing system was established using upconversion nanoparticles and 3,5-dinitrobenzoic acid (DNBA) for synergistic luminescent and colorimetric assay for strong visual detection of creatinine.
View Article and Find Full Text PDFA high-throughput, microplate reader-based method to monitor in vitro HIV latency reversal in the absence of flow cytometry.
Virology
January 2025
The Wistar Institute of Anatomy and Biology, Philadelphia, PA, USA. Electronic address:
J-Lat cells are derivatives of the Jurkat CD4 T cell line that contain a non-infectious, inducible HIV provirus with a GFP tag. While these cells have substantially advanced our understanding of HIV latency, their use by many laboratories in low and middle-income countries is restricted by limited access to flow cytometry. To overcome this barrier, we describe a modified J-Lat assay using a standard microplate reader that detects HIV-GFP expression following treatment with latency-reversing agents (LRAs).
View Article and Find Full Text PDFUltrasensitive point-of-care multiplex diagnosis for influenza virus based robust quantum dot microsphere-lateral flow immunoassay.
Biosens Bioelectron
January 2025
Key Lab for Special Functional Materials of Ministry of Education, and School of Nanoscience and Materials Engineering, Henan University, 475004, Kaifeng, China. Electronic address:
Influenza A virus (IAV) and influenza B virus (IBV) with similar symptoms of infection caused a serious disease burden and economic losses in annual epidemic season, so it is important to quickly and accurately detect and distinguish between IAV and IBV during influenza season. Herein, the quantum dot microspheres (QDMS) were synthesized and applied to lateral flow immunoassays (LFIA), and a point-of-care (POC) biosensor that can discriminately and simultaneously diagnose IAV and IBV within 10 min was established. A double-sandwich QDMS nanotags was synthesized by immobilizing hydrophobic quantum dots (QDs) with chemical bonding method on a silica sphere template with an outer silica shell protection showed excellent stability and high fluorescence.
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