Currently, it is a concerned project in medicine to study the effective methods for treatment of organophosphate (OP) poisoning. Huperzine A is a potent, reversible red cells acetylcholinesterases (AChE) inhibitor, which shows high specificity for AChE preserving scavenger capacity of plasma butyrylcholinesterase (BuChE) for OP agents, and cross the blood-brain barrier smoothly preventing the AChE in CNS, so the CNS damages induced by the acute OP poisoning were prevented. These review summarizes the results of experimental in animals, prevention mechanism, and prevention value of HupA against OP poison.
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