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Utilizing structural MRI and unsupervised clustering to differentiate schizophrenia and Alzheimer's disease in late-onset psychosis.
Behav Brain Res
March 2025
Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, New York, NY, USA.
Article Synopsis
- Late-onset psychosis (LOP) is a complex and poorly understood condition that could stem from late-onset schizophrenia or Alzheimer's disease, making accurate diagnosis crucial for effective treatment.
- * This study used structural MRI data from 699 healthy individuals and 469 patients with schizophrenia or Alzheimer's to employ data-driven techniques, specifically K-means clustering, to differentiate between these conditions.
- * Findings indicated that structural differences, such as larger right putamen volumes in schizophrenia patients, could help in distinguishing between AD and SCZ, highlighting the need for better diagnostic tools for LOP.
Polygenic score analyses on antidepressant response in late-life depression, results from the IRL-GRey study.
Pharmacogenomics J
November 2024
Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, ON, Canada.
Late-life depression (LLD) is often accompanied by medical comorbidities such as psychiatric disorders and cardiovascular diseases, posing challenges to antidepressant treatment. Recent studies highlighted significant associations between treatment-resistant depression (TRD) and polygenic risk score (PRS) for attention deficit hyperactivity disorder (ADHD) in adults as well as a negative association between antidepressant symptom improvement with both schizophrenia and bipolar. Here, we sought to validate these findings with symptom remission in LLD.
View Article and Find Full Text PDFHarnessing Brainwave Entrainment: A Non-invasive Strategy To Alleviate Neurological Disorder Symptoms.
Ageing Res Rev
November 2024
Molecular Neuroscience and Functional Genomics Laboratory, Department of Biotechnology, Delhi Technological University (Formerly Delhi College of Engineering), Shahbad Daulatpur, Bawana Road, Delhi 110042, India. Electronic address:
From 1990-2019, the burden of neurological disorders varied considerably across countries and regions. Psychiatric disorders, often emerging in early to mid-adulthood, are linked to late-life neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. Individuals with conditions such as Major Depressive Disorder, Anxiety Disorder, Schizophrenia, and Bipolar Disorder face up to four times higher risk of developing neurodegenerative disorders.
View Article and Find Full Text PDFSex-specific associations between sex hormones and clinical symptoms in late-life schizophrenia.
Schizophr Res
May 2024
The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China; Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province, Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. Electronic address:
The prevalence of late-life schizophrenia is increasing with high burden. It is well-documented that schizophrenia affects men and women differently in terms of symptoms. Sex hormones, which play a role in the pathology and symptoms of schizophrenia, are greatly affected by aging.
View Article and Find Full Text PDFCross-disorder GWAS meta-analysis of endocannabinoid DNA variations in major depressive disorder, bipolar disorder, attention deficit hyperactivity disorder, autism spectrum disorder, and schizophrenia.
Psychiatry Res
December 2023
Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada. Electronic address:
The endocannabinoid system (ECS) is implicated in multiple mental disorders. In this study, we explored DNA variations in the ECS across major depressive disorder (MDD), bipolar disorder, attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and schizophrenia by performing a cross-disorder genome-wide association study (GWAS) meta-analysis. We obtained six datasets from the Psychiatric Genomics Consortium containing GWAS summary statistics from European cohorts (284,023 cases and 508,515 controls).
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