Objective: To assess the association between polymorphisms within the interferon-Gamma receptor gene(IFN-GammaR) and systemic lupus erythematosus (SLE) in Chinese people.
Methods: The IFN-GammaR genotypes of 94 SLE patients and 80 healthy subjects were examined by the reverse transcription-polymerase chain reaction (RT-PCR)-single-strand conformation polymorphism (SSCP) method, RT-PCR-restriction fragment length polymorphism (RFLP) method and DNA sequencing.
Results: There was no statistically significant difference in the IFN-GammaR genotype frequencies between the two groups. The IFN-Gamma R2 Arg64/Arg64 genotype decreased the risk of SLE (OR = 2.481, 95% CI 0.992 - 6.203, P = 0.047). The decreased risk of the development of SLE was detected in the individuals who had the combination of IFN-GammaR2 Arg64/Arg64 genotype and IFN-GammaR1 Val14/Val14 genotype (OR = 2.481, 95% CI 0.992 - 6.203, P = 0.047).
Conclusion: The IFN-GammaR2 Arg64/Arg64 genotype does not determine susceptibility to SLE in Chinese people, and the combination of IFN-Gamma R2 Arg64/Arg64 genotype and IFN-Gamma R1 Val14/Val14 genotype does not, either.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Positive correlation between Beta-3-Adrenergic Receptor (ADRB3) gene and gout in a Chinese male population.
J Rheumatol
April 2011
Shandong Provincial Key Laboratory of Metabolic Diseases, Qingdao Key Laboratory of Common Diseases Gout Laboratory, the Affiliated Hospital of the Medical College, Qingdao University, Qingdao, Shandong, China.
Objective: The common polymorphism rs4994 [c. T387C, p. Trp64Arg (W64R)] of the lipolysis regulator beta-3-adrenergic receptor (ADRB3) was identified as a marker in the pathogenesis of hyperuricemia.
View Article and Find Full Text PDFbeta(3)-adrenergic receptor polymorphism and metabolic syndrome in postmenopausal women.
Gynecol Endocrinol
March 2008
Department of Health Promotion, University School of Physical Education, Wroclaw, Poland.
Objectives: Some studies indicate that the Trp64Arg polymorphism in the gene encoding the beta(3)-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus. The aim of the present study was to evaluate the frequency of ADRB3 polymorphism and its association with metabolic syndrome in postmenopausal women.
Methods: We performed the study on 284 randomly chosen postmenopausal women, aged 50-60 years, who were then selected to the study.
Influence of the Trp64Arg polymorphism in the beta 3 adrenoreceptor gene on insulin resistance, adipocytokine response, and weight loss secondary to lifestyle modification in obese patients.
Eur J Intern Med
December 2007
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain.
Background: The aim of our study was to investigate the influence of the Trp64Arg polymorphism in the beta 3 adrenoreceptor gene on adipocytokine response, insulin resistance, and weight loss secondary to lifestyle modification (Mediterranean hypocaloric diet and exercise) in obese patients.
Methods: A population of 65 obese (BMI >30) non-diabetic outpatients was analyzed in a prospective way. Before and after 3 months of a lifestyle modification program, indirect calorimetry, bioimpedance, blood pressure, serial assessment of nutritional intake for 3 days via written food records, and biochemical analysis were performed.
Correlation between some Th1 and Th2 cytokine receptor gene polymorphisms and systemic lupus erythematosus in Chinese patients.
Int J Dermatol
November 2007
Institute of Dermatology, Chinese Academy of Medical Science, Nanjing, China.
Background: Genetic factors seem to play a significant role in the susceptibility to systemic lupus erythematosus (SLE). Some researchers have described amino acid polymorphisms within the interleukin-4 receptor (IL-4R) [isoleucine50valine (Ile50Val), arginine576glutamine (Arg576Gln), etc.], the IL-10R (G241A and G520A), and the interferon-gamma receptor (IFN-gammaR) [valine14methionine (Val14Met) and glutamine64arginine (Gln64Arg)].
View Article and Find Full Text PDFPost-exercise oxidative stress and obesity in postmenopausal women: the role of beta3-adrenergic receptor polymorphism.
Gynecol Endocrinol
October 2007
Department of Health Promotion, University School of Physical Education, Wroclaw, Poland.
Aim: Some studies indicate that the Trp64Arg polymorphism in the gene encoding the beta3-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus. The aim of the present study was to evaluate the frequency of this polymorphism and its relationship with obesity and oxidative stress in postmenopausal women.
Material And Methods: We performed the study on 200 women, aged 50-60 years.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!