Apoptosis programmed cell death takes place in response to many different stimuli, which include DNA damage. This is interest for therapeutic and prognostic purposes in neoplasms. Laboratory studies have shown that many anti-cancer agents (including cytostatics) achieve their cytotoxic effect by inducing apoptosis. Flow cytometry methods have found application in identification and enumeration of apoptotic cells, which were used in the present study. The retrospective study concerning children and adolescents osteosarcomas has shown, that longer survival time correlated with higher apoptotic index (apoptotic cells in "pre-G1/G0" position of DNA histograms) in tumours after preoperative chemotherapy. Shorter survival time (up to 3 years) correlated with small apoptotic population and bigger aneuploid fraction. This suggests that response to applied chemotherapy of these osteosarcomas was relatively small. These preliminary results have shown, that estimation of the apoptotic population can be helpful in prognosis and effects of chemotherapy. It should be confirmed on fresh tumour material after preoperative chemotherapy and longer clinical observation.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The utility of routine intraoperative CSF during ventricular shunt insertion: a 10-year retrospective cohort study.
J Neurosurg Pediatr
January 2025
1Department of Neurosurgery, Queensland Children's Hospital, Brisbane; and.
Objective: Ventricular shunt insertion is a common procedure in pediatric neurosurgical practice. In many areas of medicine there is a push toward rationalization of healthcare resources and a reduction in low-value tests or procedures. The intraoperative sampling of CSF at the time of shunt insertion is one traditional aspect of care that has not been rigorously evaluated.
View Article and Find Full Text PDFClassification-augmented survival estimation (CASE): A novel method for individualized long-term survival prediction with application to liver transplantation.
PLoS One
January 2025
Division of Gastroenterology & Hepatology, University of Toronto, Toronto, ON, Canada.
Survival analysis is critical in many fields, particularly in healthcare where it can guide medical decisions. Conventional survival analysis methods like Kaplan-Meier and Cox proportional hazards models to generate survival curves indicating probability of survival v. time have limitations, especially for long-term prediction, due to assumptions that all instances follow a general population-level survival curve.
View Article and Find Full Text PDFEvaluating and upgrading the performance of a bridge network structure with Rayleigh distribution lifetimes.
PLoS One
January 2025
Department of Mathematics, Aswan University, Faculty of Science, Aswan, Egypt.
In this work, bridge network model with Rayleigh distribution lifetimes is used. Two main techniques are calculated to upgrade this model: reduction and redundancy techniques. In order to compare the effectiveness of the various approaches, the survival function, the mean time to failure and gamma-fractiles for the original and upgraded model are calculated.
View Article and Find Full Text PDFIncomplete Ascertainment of Mortality in a Nationally Representative Longitudinal Study of Community-Living Older Americans.
J Gerontol A Biol Sci Med Sci
January 2025
Yale School of Public Health, Department of Biostatistics, New Haven, CT.
Background: In longitudinal studies of older persons, complete ascertainment of mortality is needed to minimize potential biases. To ascertain mortality in the National Health and Aging Trends Study (NHATS), investigators are advised to use its Sensitive files, which include month and year of death on most decedents who had not dropped out of the study. Because losses to follow-up are not insubstantial, ascertainment of mortality is likely incomplete.
View Article and Find Full Text PDFAdvancements in molecular imaging probes for precision diagnosis and treatment of prostate cancer.
J Zhejiang Univ Sci B
January 2025
Department of Orthopedics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
Prostate cancer is the second most common cancer in men, accounting for 14.1% of new cancer cases in 2020. The aggressiveness of prostate cancer is highly variable, depending on its grade and stage at the time of diagnosis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!