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EN ISO 15189 revision: EFLM Committee Accreditation and ISO/CEN standards (C: A/ISO) analysis and general remarks on the changes.
Clin Chem Lab Med
January 2025
SKML, Nijmegen, The Netherlands.
Article Synopsis
- The EN ISO 15189:2022 standard updates regulations for medical laboratories, replacing previous versions and aiming for better quality and competence.
- The revision focuses on aligning with ISO/IEC 17025:2017, enhancing patient safety, and providing clearer guidelines while minimizing new requirements.
- A guidance document from the EFLM Committee has been produced to help laboratories and accreditation bodies understand and implement these changes effectively.
Virtual On-Call: Use of Low-Fidelity Simulation to Improve Preparedness for Practice.
Cureus
November 2024
Medical Education and Simulation, Maidstone and Tunbridge Wells National Health Service (NHS) Trust, Kent, GBR.
Background Many newly qualified doctors feel unprepared for clinical practice. The literature identifies themes including difficulties with clinical reasoning, emergency management, handover, and prioritization of tasks. Although there is an expected level of anxiety for newly qualified doctors, this appears to be amplified with respect to the first on-call shifts that encompass these themes.
View Article and Find Full Text PDFStimulator of interferon genes-associated vasculopathy with onset in infancy (SAVI syndrome).
Eur Ann Otorhinolaryngol Head Neck Dis
December 2024
Servicio de Otorrinolaringología, Hospital Universitario y Politécnico La Fe, Valencia, Spain; Departamento de Cirugia, Facultat de Medicina i Odontologia, Universitat de València, Valencia, Spain; Instituto de Investigación Sanitaria (IIS) La Fe, Valencia, Spain; BMCG, Instituto de Investigación Sanitaria La Fe, CIBERES, Valencia, Spain.
Introduction: To document through a case report the ENT manifestations of the STING-associated vasculopathy with onset in infancy (SAVI) syndrome, remarking their value to achieve the diagnosis.
Case Summary: A man in his forties presented with exercise-related dyspnoea and cold-exacerbated painful lesions over the nasal tip, cheeks, ears, and feet since his early childhood. The ENT manifestations included cartilaginous necrosis (both auricles and nasal tip) and a 1-cm anterior septal perforation.
From acute lung injury to cerebral ischemia: a unified concept involving intercellular communication through extracellular vesicle-associated miRNAs released by macrophages/microglia.
Clin Exp Immunol
December 2024
Digestive minimally invasive center, The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014030, China.
Ischemic stroke and acute lung injury are prevalent life-threatening conditions marked by intricate molecular mechanisms and elevated mortality rates. Despite evident pathophysiological distinctions, a notable similarity exists in the gene responses to tissue injury observed in both pathologies. This similarity extends to both protein-encoding RNAs and non-coding RNAs.
View Article and Find Full Text PDFFingolimod Inhibits C6 Rat Glioma Proliferation and Migration, Induces Sub-G1 Cell Cycle Arrest, Mitochondrial and Extrinsic Apoptosis In Vitro and Reduces Tumour Growth In Vivo.
Clin Exp Pharmacol Physiol
January 2025
Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Article Synopsis
- Glioblastoma multiforme (GBM) is a highly aggressive brain tumor that is currently incurable, highlighting the need for new treatment options.
- This study explored the effects of fingolimod, a drug known for its anti-cancer properties, on C6 rat brain cancer cells using various tests to assess cell survival, proliferation, and apoptosis.
- Results showed that fingolimod significantly reduced cell survival and tumor growth in rats, indicating that it may work by inducing cell cycle arrest and apoptosis in GBM cells.
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