Several bradykinin potentiators were identified in the venom of Bothrops jararacussu by chromatographic techniques and biological assays. One of them which was isolated inhibited the angiotensin-converting enzyme in vitro and potentiated the bradykinin-induced lowering of the arterial pressure in the rat.
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http://dx.doi.org/10.1016/0041-0101(92)90499-u | DOI Listing |
Int J Biol Macromol
January 2025
Fundação de Medicina Tropical - Dr Heitor Vieira Dourado, Manaus, AM, Brazil; Universidade Nilton Lins, Manaus, AM, Brazil. Electronic address:
Toxicon
January 2025
Laboratório de Fisiopatologia, Instituto Butantan, São Paulo, Brazil; Laboratório de Herpetologia, Instituto Butantan, São Paulo, Brazil; Interunidades em Biotecnologia, Universidade de São Paulo - Instituto de Pesquisas Tecnológicas - Instituto Butantan, São Paulo, Brazil. Electronic address:
Fibrinogen is a common target of SVMP and SVSP. These toxins can destructively cleave fibrinogen, leading to the depletion of its levels. Herein we comparatively describe the fibrinogenolytic activity of the venom of Bothrops and Crotalus snakes, viperids of high epidemiological importance in Brazil.
View Article and Find Full Text PDFToxicon
January 2025
Laboratório de Fisiopatologia, Instituto Butantan, São Paulo, Brazil; Programa de Pós-Graduação Interunidades em Biotecnologia, São Paulo, Brazil; Laboratório de Fisiopatologia, Instituto Butantan, São Paulo, Brazil. Electronic address:
Coagulation disorders are a primary symptom of envenomation caused by snakes belonging to the genus Bothrops. In the Northeast region of Brazil, the species Bothrops erythromelas and Bothrops leucurus are the main responsible for snakebite accidents. Due to the specific action of Bothrops venoms on several components of the coagulation cascade, the objective of this work was to characterize the coagulotoxic profile of B.
View Article and Find Full Text PDFChem Sci
January 2025
LAQV/Requimte, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto Rua do Campo Alegre, s/n 4169-007 Porto Portugal
Snake venom-secreted phospholipases A (svPLAs) are critical, highly toxic enzymes present in almost all snake venoms. Upon snakebite envenomation, svPLAs hydrolyze cell membrane phospholipids and induce pathological effects such as paralysis, myonecrosis, inflammation, or pain. Despite its central importance in envenomation, the chemical mechanism of svPLAs is poorly understood, with detrimental consequences for the design of small-molecule snakebite antidotes, which is highly undesirable given the gravity of the epidemiological data that ranks snakebite as the deadliest neglected tropical disease.
View Article and Find Full Text PDFChem Biodivers
January 2025
Federal Fluminense University: Universidade Federal Fluminense, Molecular and Cellular Biology, . Prof. Marcos Waldemar de Freitas Reis - São Domingos, Bloco M, Campus Gragoatá, 24210-201, Niteroi, BRAZIL.
Snakebite envenomation is a public health issue that can lead to mortality and physical consequences. It is estimated that 5.4 million venomous snake bites occur annually, with 130,000 deaths and 400,000 amputations.
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