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Chitosan-PVA-PVP/nano-clay composite: a promising tool for controlled drug delivery.
RSC Adv
May 2024
Department of Pharmaceutics, College of Pharmacy, King Saud University PO BOX 2457 Riyadh 11451 Kingdom of Saudi Arabia
In this study, chitosan, polyvinyl alcohol (PVA), and polyvinyl pyrrolidone (PVP) were used to create ternary blends reinforced with organically modified montmorillonite nanoclay. Tramadol was used as a model drug to assess the efficacy of these ternary blends as drug delivery systems. The current work demonstrated the highly controlled release of tramadol transdermal administration.
View Article and Find Full Text PDFHarmonising IV Oxycodone with Paediatric Perioperative Medications: A Compatibility Study Through Y-Type Connectors.
Drug Des Devel Ther
March 2024
Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Purpose: Co-administering multiple intravenous (IV) agents via Y-connectors is a common practice in hospitalised and fasting surgical patients. However, there is a lack of reliable data confirming the physical compatibility of some combinations including IV oxycodone, a drug that is gaining increasing popularity in the perioperative period. Concern regarding physical drug incompatibilities precludes concurrent coadministration with other common drugs through a single lumen.
View Article and Find Full Text PDFPhysical compatibility of colistin with analgesics during simulated Y-site administration.
Am J Health Syst Pharm
June 2024
Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Poznań, Poland.
Purpose: Special consideration is needed when intravenous drugs are administered simultaneously using a Y-site connector. This study aimed to investigate the physical compatibility of colistin with 6 analgesics at concentrations commonly used in clinical practice.
Methods: A pharmaceutical preparation of colistin was dissolved according to the manufacturer's instructions and diluted to a concentration of 1.
Simultaneous determination of 14 analgesics in postoperative analgesic solution by HPLC-DAD and LC-MS/MS.
BMC Chem
January 2024
Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, 442008, People's Republic of China.
A green, efficient, sensitive and accurate detection method by HPLC-DAD and LC-MS/MS was developed and validated for the quantification of morphine, hydromorphone, oxycodone, ketamine tramadol, dezocine, ropivacaine, remifentanil, butorphanol, bupivacaine, droperidol, fentanyl, lornoxicam and sufentanil. The 14 mixtures were chromatographed via HPLC-DAD method which employed 0.05 mol/L potassium dihydrogen phosphate solution-acetonitrile as the mobile phase, the analytes were gradient elution on a SinoChrom ODS-BP C column with a total separation time of 35 min, and 14 mixtures showed a good linear relationship in the linear range.
View Article and Find Full Text PDFPersistent socket pain in a dog after the enucleation of the eye and its clinical management.
Vet Med Sci
November 2023
Dick White Referrals, Six Mile Botton, Cambridgeshire, UK.
Article Synopsis
- Persistent socket pain occurs in dogs after eye removal, mirroring the condition seen in humans post-enucleation.
- A 10-year-old dog underwent eye removal but continued to show signs of discomfort despite medication, leading to further investigation and an MRI that revealed orbital cellulitis.
- Treatment involving an injection of local anesthetic and steroid significantly relieved the dog's pain, demonstrating the importance of accurate diagnosis and effective intervention for this condition.
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