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Cardiotoxic Effects Following CAR-T Cell Therapy: A Literature Review.
Curr Oncol Rep
January 2025
Department of Radiology, Albert Einstein College of Medicine and the Montefiore Medical Center, 111 East 210Th Street, Bronx, NY, 10461, USA.
Purpose Of Review: This paper reviewed the current literature on incidence, clinical manifestations, and risk factors of Chimeric Antigen Receptor T-cell (CAR-T) cardiotoxicity.
Recent Findings: CAR-T therapy has emerged as a groundbreaking treatment for hematological malignancies since FDA approval in 2017. CAR-T therapy is however associated with a few side effects, among which cardiotoxicity is of significant concern.
Role of Point-of-Care Ultrasound (POCUS) in Cardiac Arrest: A Case Report.
Cureus
December 2024
Anesthesiology, Intensive Care and Emergency Department, Centro Hospitalar Universitário de Santo António, Porto, PRT.
Acute pulmonary embolism (PE) is a significant cause of cardiac arrests, with subsequent high mortality worldwide. Early recognition of acute PE allows earlier diagnosis, stabilization, and risk stratification, which are crucial in deciding the most adequate treatment option. However, diagnosis is sometimes difficult due to nonspecific clinical presentation.
View Article and Find Full Text PDFHead to Toe: A Perioperative Surgical Home Approach to Sepsis and Airway Obstruction in a Geriatric Patient.
Cureus
December 2024
Department of Anesthesiology and Perioperative Medicine, Riverside University Health System Medical Center, Moreno Valley, USA.
The perioperative surgical home (PSH) is a care delivery model designed to improve the perioperative and long-term outcomes of patients undergoing surgery by promoting holistic care and seamless cooperation between different services and subspecialties. An aging population and increased surgical complexity have led to renewed interest in PSH models. An 86-year-old female with diabetes and critical limb ischemia presented with sepsis due to right calcaneal gangrene.
View Article and Find Full Text PDFClinically interpretable multiclass neural network for discriminating cardiac diseases.
Heliyon
January 2025
Department of Information Engineering, Università Politecnica delle Marche, via Brecce Bianche, Ancona, 60131, Italy.
Background: Deep-learning applications in cardiology typically perform trivial binary classification and are able to discriminate between subjects affected or not affected by a specific cardiac disease. However, this working scenario is very different from the real one, where clinicians are required to recognize the occurrence of one cardiac disease among the several possible ones, performing a multiclass classification. The present work aims to create a new interpretable deep-learning tool able to perform a multiclass classification and, thus, discriminate among several different cardiac diseases.
View Article and Find Full Text PDFApplication prospect of speckle tracking echocardiography in pacemaker implantation.
Front Cardiovasc Med
January 2025
Department of Cardiology, The First People's Hospital of Neijiang, Neijiang, China.
More than 1 million permanent pacemakers are implanted worldwide each year, half of which are in patients with high-grade atrioventricular block. Pacemakers provide adequate frequency support in the initial stage, but traditional right ventricular (RV) pacing may lead to or aggravate left ventricular dysfunction and arrhythmia. Several potential risk factors for heart failure and arrhythmias after pacemaker surgery have been identified, but their occurrence remains difficult to predict clinically.
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