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Cytokines as potential biomarkers for the diagnosis of infection in Mediterranean buffaloes ().
Front Vet Sci
December 2024
National Reference Centre for Hygiene and Technologies of Mediterranean Buffalo Farming and Productions, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Salerno, Italy.
() is the primary agent of bovine tuberculosis (TB) in Mediterranean buffalo, which has a negative economic impact on buffalo herds. Improving TB diagnostic performance in this species represents a key step to eradicate efficiently this disease. We have recently shown the utility of the IFN-γ assay in the diagnosis of infection in Mediterranean buffaloes (), but other cytokines might be useful immunological biomarkers of this infection.
View Article and Find Full Text PDFBlood levels of Mycobacterium tuberculosis (Mtb)antigen-triggered immune markers in people exposed to tuberculosis with regard to Mtb infection status and receipt of tuberculosis preventive therapy.
Tuberculosis (Edinb)
December 2024
Clinical Infection Medicine, Department of Translational Medicine, Lund University, Ruth Lundskogs gata 3, SE214 28, Malmö, Sweden.
Background: Interferon-γ release assays (IGRAs) for tuberculosis infection (TBI) cannot distinguish different stages of the TBI spectrum (including spontaneously cleared infection). We investigated patterns of Mtb-specific blood mediators in people with and without TBI during tuberculosis preventive therapy (TPT).
Methods: Individuals with likelihood of recent Mtb exposure, aged 15-25 years, with valid IGRA results, in whom tuberculosis (TB) had been excluded, were included.
The Synergic Immunomodulatory Effect of Vitamin D and Chickpea Protein Hydrolysate in THP-1 Cells: An In Vitro Approach.
Int J Mol Sci
November 2024
Group of Plant Proteins, Instituto de la Grasa-CSIC, 41013 Seville, Spain.
Article Synopsis
- Vitamin D (VD) plays a key role in bone health and immune function and may help protect against chronic inflammatory diseases.
- The study involved treating THP-1 cells with VD and a chickpea protein hydrolysate (H30BIO) to assess their effects on inflammation and cytokine production.
- Results showed that while VD alone reduced pro-inflammatory gene expression and cytokine levels, combining VD with H30BIO enhanced certain gene expressions, indicating a potential synergistic effect in modulating inflammation.
Transcriptome Profiling Unveils the Mechanisms of Inflammation, Apoptosis, and Fibrosis in the Liver of Juvenile Largemouth Bass Fed High-Starch Diets.
Animals (Basel)
November 2024
Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), College of Fisheries, Southwest University, Chongqing 400715, China.
The aim of this study was to explain the mechanism underlying the liver injury of juvenile largemouth bass in response to high-starch diet intake. Three diets were formulated with different starch levels, being abbreviated as treatment LS (low starch, 8.13% starch), MS (medium starch, 14.
View Article and Find Full Text PDFmRNA-LNPs induce immune activation and cytokine release in human whole blood assays across diverse health conditions.
Mol Ther
December 2024
Drug Safety Research and Development, Pfizer Inc, Groton, CT 06340, USA. Electronic address:
RNA medicines have become a promising platform for therapeutic use in recent years. Understanding the immunomodulatory effects of novel mRNA-lipid nanoparticles (LNPs) is crucial for future therapeutic development. An in vitro whole blood assay was developed to assess the impact of mRNA-LNPs on immune cell function, cytokine release, and complement activation.
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