Although its significance remains unknown, it has recently been reported that epidermal papillomatous hyperplasia could be frequently found in extramammary Paget's disease (EMPD). The simultaneous occurrence of EMPD and various human-papillomavirus (HPV)-associated neoplasms has also been reported. We report a case of a perianal EMPD with multiple verrucous papules on its surface. Histologically, the verrucous papules consisted of two distinct histological patterns; one showed numerous Paget's cells within the hyperplastic epidermis with papillomatosis, and the other showed the features compatible with condyloma acuminatum (CA). HPV-6 DNA was demonstrated in koilocytic keratinocytes of the CA by in situ hybridization. No positive signal was obtained for targeted HPV type 6/11/16/18/31/33 DNA in either the verrucous or plaque EMPD. Since the verrucous papules were localized on the plaque of EMPD, our case suggests that some undetermined EMPD-related factors may contribute to the development of epithelial hyperplasia, including HPV-associated neoplasms.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000084756 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deep Fungal Infections of Skin and Role of Histopathology in Diagnosis.
Indian J Dermatol
October 2024
Department of Dermatology, Institute of Child Health, Kolkata, India.
Introduction: Deep mycoses acquired by penetrating trauma to the skin can have varied and sometimes atypical morphological presentations resulting in diagnostic dilemmas and delay in treatment onset. Histopathology can be a useful tool in not only diagnosing but also differentiating various deep mycoses.
Aims And Objectives: To observe various morphological presentations and histopathological features of deep fungal infections.
Treatment-Resistant Chromoblastomycosis Successfully Managed With Surgical Excision.
Cureus
November 2024
Dermatology, University of California Davis Medical Center, Sacramento, USA.
Chromoblastomycosis is an uncommon, chronic granulomatous fungal infection of the skin and subcutaneous tissue. Chromoblastomycosis is most commonly caused by the traumatic inoculation of dematiaceous (pigmented) fungi, most commonly species, species, and species. Chromoblastomycosis usually affects agricultural workers in tropical and subtropical climates.
View Article and Find Full Text PDFConventional versus daylight photodynamic therapy for recalcitrant hand warts: Efficacy, safety and recurrence.
Photodiagnosis Photodyn Ther
December 2024
Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, Messina 98125, Italy. Electronic address:
Article Synopsis
- Acral warts, common on hands and feet, can be treated with conventional photodynamic therapy (C-PDT), which has been effective and safe for both adults and children, but the efficacy of daylight photodynamic therapy (DL-PDT) is still unclear.
- A study involving 68 patients aimed to compare the short- and long-term effects of C-PDT and DL-PDT using 10% aminolevulinic acid (ALA) on hand warts, with evaluations of responses occurring at 3 months and 1 year post-treatment.
- Results showed that both treatments were generally effective and well-tolerated, with a majority of patients experiencing excellent responses; however, a notable percentage had warts relapse a year later
Successful combination therapy of trichloroacetic acid, podophyllin, and electrocautery on giant condylomata acuminata.
Int J STD AIDS
November 2024
Department of Dermatology, Venereology, and Aesthetics, Dr Mohammad Hoesin General Hospital, Faculty of Medicine Universitas Sriwijaya, Palembang, Indonesia.
Giant condylomata acuminata (GCA) is a rare presentation of anogenital wart (AGW), invasive locally but does not metastasize. Combination therapy for GCA is suggested based on modalities and experiences. The combination of TCA and podophyllin has showed good efficacy, followed by electrocautery to eradicate warts.
View Article and Find Full Text PDFA case of multiple soft fibromas complicated with pityriasis versicolor during pregnancy: A case report.
SAGE Open Med Case Rep
August 2024
Institute of Traditional Chinese Medicine of Sichuan Academy of Chinese Medicine Sciences, Chengdu City, Sichuan Province, China.
Article Synopsis
- Dermatological conditions during pregnancy can impact both maternal and fetal health, creating unique management challenges.
- A 32-year-old pregnant woman at 36 weeks experienced skin issues like melanotic papules and neoplasms and sought medical advice regarding the effects on her baby.
- Although she chose not to receive treatment while pregnant, her skin lesions improved naturally after childbirth, and both she and her child remained healthy long-term, highlighting the need for comprehensive care in such cases.*
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!