Real-time recurrent learning (RTRL), commonly employed for training a fully connected recurrent neural network (RNN), has a drawback of slow convergence rate. In the light of this deficiency, a decision feedback recurrent neural equalizer (DFRNE) using the RTRL requires long training sequences to achieve good performance. In this paper, extended Kalman filter (EKF) algorithms based on the RTRL for the DFRNE are presented in state-space formulation of the system, in particular for complex-valued signal processing. The main features of global EKF and decoupled EKF algorithms are fast convergence and good tracking performance. Through nonlinear channel equalization, performance of the DFRNE with the EKF algorithms is evaluated and compared with that of the DFRNE with the RTRL.
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http://dx.doi.org/10.1109/TNN.2005.845142 | DOI Listing |
Brief Bioinform
November 2024
Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
This study aimed to investigate the genetic association between glioblastoma (GBM) and unsupervised deep learning-derived imaging phenotypes (UDIPs). We employed a combination of genome-wide association study (GWAS) data, single-nucleus RNA sequencing (snRNA-seq), and scPagwas (pathway-based polygenic regression framework) methods to explore the genetic links between UDIPs and GBM. Two-sample Mendelian randomization analyses were conducted to identify causal relationships between UDIPs and GBM.
View Article and Find Full Text PDFBioinformatics
January 2025
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Motivation: The accurate prediction of O-GlcNAcylation sites is crucial for understanding disease mechanisms and developing effective treatments. Previous machine learning models primarily relied on primary or secondary protein structural and related properties, which have limitations in capturing the spatial interactions of neighboring amino acids. This study introduces local environmental features as a novel approach that incorporates three-dimensional spatial information, significantly improving model performance by considering the spatial context around the target site.
View Article and Find Full Text PDFMed Phys
January 2025
Deparment of Radiation Oncology, Duke University, Durham, North Carolina, USA.
Background: Stereotactic radiosurgery (SRS) is widely used for managing brain metastases (BMs), but an adverse effect, radionecrosis, complicates post-SRS management. Differentiating radionecrosis from tumor recurrence non-invasively remains a major clinical challenge, as conventional imaging techniques often necessitate surgical biopsy for accurate diagnosis. Machine learning and deep learning models have shown potential in distinguishing radionecrosis from tumor recurrence.
View Article and Find Full Text PDFUnderstanding how the collective activity of neural populations relates to computation and ultimately behavior is a key goal in neuroscience. To this end, statistical methods which describe high-dimensional neural time series in terms of low-dimensional latent dynamics have played a fundamental role in characterizing neural systems. Yet, what constitutes a successful method involves two opposing criteria: (1) methods should be expressive enough to capture complex nonlinear dynamics, and (2) they should maintain a notion of interpretability often only warranted by simpler linear models.
View Article and Find Full Text PDFRate equations and numerical simulations relying on complex mathematical and physical principles are typically used to model directly modulated lasers (DMLs) but have difficulty simulating dynamic DML behavior in real-time under varying conditions due to their high complexity. Here, we introduce a data-driven deep learning method to model DMLs, aiming to achieve high accuracy with reduced computational complexity. This approach employs bidirectional long short-term memory (BiLSTM) enhanced by advanced feature recalibration and nonlinear fitting techniques.
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